ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients

Simmaron’s Spinal Fluid Study Finds Dramatic Differences in Chronic Fatigue Syndrome

5 Lessons I Have Learned Living With Chronic Illness

The Countess of Mar, Medical Politics, and ME/CFS

What were your first symptoms of ME/CFS?

Life for a Young Person with M.E.

Cultivating Self-Compassion

ProHealth's 2014 Advocate of the Year – Ryan Prior

World Famous Joint Relief Formula Enhanced by Modern Science

Autoimmune Organization Makes Urgent Call For Fatigue Research

 
Print Page
Email Article

Constellation of 5 immune markers - may be diagnostic for post mono ME/CFS

  [ 7 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 15, 2012


Article:
Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue
- Source: Translational Medicine, Sep 13, 2012

By Gordon Broderick, MD, et al.

[Note: A provisional full text PDF of this article is available at http://www.translational-medicine.com/content/pdf/1479-5876-10-191.pdf.  This study by ME/CFS researchers at clinics in Canada and several US states measured a broad range of cytokines, using uniform laboratory protocols, in patients diagnosed according to uniform criteria, all after infection with the same pathogen (Epstein-Barr) and all still ill at 24 months post infection. Cytokines, produced by the immune system, are involved in the inflammatory response.]

Abstract:
Background: As Chronic Fatigue Syndrome (CFS) has been known to follow Epstein-Bar virus (EBV) and other systemic infections, our objective was to describe differences in immune activation in:

• Post-infective CFS (PI-CFS) patients

• And recovered controls.

We studied 301 adolescents prospectively over 24 months following the diagnosis of monospot-positive infectious mononucleosis (IM).

We found an incidence of CFS at 6, 12 and 24 months of 13%, 7% and 4% respectively.

Methods: Using chemiluminescent imaging we measured the concentrations of IL-1a, 1b, 2, 4, 5, 6, 8, 10, 12 (p70), 13, 15, 17 and 23, IFN-gamma, TNF-alpha and TNF-beta in duplicate plasma samples available in bio-bank from 9 PI-CFS subjects and 12 recovered controls at 24 months post-infection.

Results:

Standard comparative analysis indicated significant differences in IL-8 and 23 across subject groups.

In constructing a linear classification model IL-6, 8 and 23 were selected by two different statistical approaches as discriminating features, with IL-1a, IL-2 and IFN-gamma also selected in one model or the other.

This supported an assignment accuracy of better than 80% at a confidence level of 0.95 into PI-CFS versus recovered controls.

Conclusion: These results suggest that co-expression patterns in as few as 5 cytokines associated with Th17 function may hold promise as a tool for the diagnosis of post-infectious CFS.

Source: Translational Medicine, Sep 13, 2012. PMID: 22973830, by Groderick G, Katz BZ, Fernandes H, Fletcher MA, Klimas NG, Smith FA, O’Gorman MRG, Vernon SD, Taylor R. University of Alberta, Edmonton, Alberta, Canada; Children’s Memorial Hospital, Chicago, Illinois; University of Miami, Florida; Miami Veterans Affairs Medical Center, Miami, Florida; Feinberg School of Medicine, Northwestern, Chicago, Illinois; CFIDS Assoc. of America, Charlotte, North Carolina, USA. [Email: Gordon.broderick@ualberta.ca]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness

Natural Remedies

Complete and Natural Menopause Relief Complete and Natural Menopause Relief
The 10 Supplements Dr. Teitelbaum Recommends Most Often for Those with Top Health Issues The 10 Supplements Dr. Teitelbaum Recommends Most Often for Those with Top Health Issues
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing