ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Chronic fatigue syndrome and fibromyalgia in diagnosed sleep disorders: a further test of the ‘unita...

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

May 12 International ME/CFS, Lyme, and FM Awareness Day

A Missing Subset in ME/CFS and Fibromyalgia Revealed? Take the Disease Course Survey

The role of Epstein-Barr virus infection in the development of autoimmune thyroid diseases

Heroes Amidst the Daily Grind of Chronic Illness

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

Looking After Yourself Isn’t Selfish

Adapting Successfully to Long Term Illness – May Start with Dumping the Denial

Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses

 
Print Page
Email Article

Lyrica and Statin Drug Combo Thought to Cause Rhabdomyolysis: A Case Report

  [ 3 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 8, 2012


[Note: to read the full text of the article, click HERE ]

Article:

Pregabalin and simvastatin: first report of a case of rhabdomyolysis
– Source: Pharmacy and Therapeutics, October 2012

by Michele B. Kaufman and Mary Choy

Abstract:

Purpose: We sought to determine whether a case of rhabdomyolysis was a probable adverse reaction associated with pregabalin (Lyrica) and simvastatin (Zocor). [Note: Rhabdomyolysis is the breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream. Myoglobin is harmful to the kidney and often causes kidney damage.] Pregabalin is not recognized as a cause of rhabdomyolysis, but statins are known to cause it.

 

Patient Summary: A 70-year-old man with a history of fibromyalgia, type-2 diabetes, hypercholesterolemia, and chronic back pain presented to the emergency department with altered mental status, limb weakness, twitching, and slurred speech.

 

He was taking multiple pain and neuropathic medications and had recently started taking lisinopril (e.g., Zestril) and simvastatin. His pregabalin dose was also increased from 50 mg to 100 mg three times daily. On admission, serum creatinine (SCr) and creatine phosphokinase (CPK) levels were 1.5 mg/dL (normal, 0.7-1.5 mg/dL) and 1,391 units/L (normal, 30-170 units/L), respectively. Metformin (Glucophage) was discontinued, and insulin was started.

 

He was alert and oriented. The review of symptoms was normal except for leg weakness. He had no seizure activity. Simvastatin was discontinued, and the patient was aggressively hydrated. The following day, the SCr level was 1.6 mg/dL and the CPK level was 14,191 units/L. Pregabalin was then discontinued.

 

The rhabdomyolysis resulted from simvastatin and perhaps also pregabalin. The Naranjo Causality Algorithm indicates a probable relationship between rhabdomyolysis and combined therapy. Three days later, the patient had significantly improved, and CPK began to decline. His discharge plan included all prior medications except simvastatin and pregabalin.

 

Conclusion: It is not well known that pregabalin can cause rhabdomyolysis, and there is only one published report on pregabalin-induced hepatotoxicity. [Note: The full-text article also states, “In the package labeling for pregabalin, three cases of rhabdomyolysis are noted in premarketing clinical trials; however, no further details are provided.”] When different therapies are combined, the risk of rhabdomyolysis may be increased.

 

The cause of rhabdomyolysis in our patient might be related to decreased renal elimination of both pregabalin and simvastatin (e.g., renal tubular reabsorption). It is important to be aware of this potentially serious and possibly life-threatening reaction especially when medication doses are increased or combined with other agents with similar safety issues.

Source: Pharmacy and Therapeutics. 2012 Oct; 37(10):579-95, by Michele B. Kaufman, PharmD and Mary Choy, PharmD.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria

Natural Remedies

Safely Burn Away Body Fat Safely Burn Away Body Fat
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing