ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Twenty-Six Years of Hell: An ME/CFS/FM Recovery Story

What Makes You Forget?

Motivation: It's Not What You Think

The Opioid Painkiller Clampdown – Will it Lead to Better Drugs?

Top 10 Gifts to People Living with Pain

An Alternative to Goals and Resolutions: Intentions and Extreme Permissiveness

Could Chronic Fatigue Syndrome (ME/CFS) Be a Chronic Form of Sepsis?

Chronic Fatigue Syndrome (ME/CFS) Researcher and Patients Shine During NIH Call

Unrest Flies High, Dr. Oz Talks ME/CFS and Ms Magazine Delivers

Urgency: Ron Davis and His (Non-NIH Funded) ME/CFS Collaborative Research Center

 
Print Page
Email Article

CoQ10 Supplementation Improves Fibromyalgia Symptoms

  [ 7 votes ]   [ 2 Comments ]
www.ProHealth.com • March 10, 2013


Can Coenzyme Q10 improve clinical and molecular parameter in Fibromyalgia?
– Source: Antioxidants and Redox Signaling, March 4, 2013

By M.D. Cordero, et al.

Abstract:

Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Its pathophysiological mechanisms are difficult to identify and current drug therapies demonstrate limited effectiveness. Both mitochondrial dysfunction and coenzyme Q10 (CoQ10) deficiency have been implicated in FM pathophysiology.

We have investigated the effect of CoQ10 supplementation. We carried out a randomized, double-blind, placebo-controlled trial to evaluate clinical and gene expression effects of forty days of CoQ10 supplementation (300mg/day), in twenty FM patients. This study was registered with controlled-trials.com (ISRCTN 21164124).

  • An important clinical improvement was shown after CoQ10 vs placebo treatment showing a reduction of FIQ [Fibromyalgia Impact Questionnaire] (P<0.001),

  • and a most prominent reduction in pain (P<0.001), fatigue and morning tiredness (P?0.01) subscales from FIQ.

  • Furthermore, we observed an important reduction in pain visual scale (P<0.01)

  • and a reduction in tender points (P<0.01), including recovery of inflammation, antioxidant enzymes, mitochondrial biogenesis and AMPK gene expression levels, associated with phosphorilation of AMPK activity.

These results lead to the hypothesis that CoQ10 have a potential therapeutic effect in FM, and indicate new potential molecular targets for the therapy of this disease. AMPK could be implicated in the pathophysiology of FM.


Source:
Antioxidants and Redox Signaling, March 4, 2013. By M.D. Cordero, E. Alcocer-Gómez, M. de Miguel, O. Culic, A.M. Carrión, J.M. Alvarez-Suarez, P. Bullon, M. Battino, A. Fernández-Rodríguez, J.A. Sánchez-Alcázar. Dpto. Citología e Histología Normal y Patológica, Facultad de Medicina. Universidad de Sevilla, 41009 Sevilla-Spain, Avda. Sánchez-Pizjuán s/n, Sevilla, Spain, 41009, +34 95 4551797 , +34 95 4551799; mdcormor@us.es





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength Hydroxocobalamin Extreme™


Article Comments Post a Comment

AND
Posted by: IanH
Mar 10, 2013
they used ubiquinone.

This is a great study showing how CoQ10 is as good as or better than any other parmaceutical prescribed for FM.

In our clinic we always use CoQ10 for FM. Working up to 200mg twice daily for three months then decline to 200mg daily thereafter.

When combined with VitB12, Magnesium, MTHF, Creatine Phos and ribose you do get a good result with most people.
Reply Reply

COQ10 dosage
Posted by: Diegolady
Mar 14, 2013
The article doesn't state what dosage they used in the study. I have used COQ10, but never know what dosage to use. Now I will go with the 200 mg daily. Thanks.
Reply Reply
 
Optimized Curcumin Longvida with Omega-3

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map