ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

The END ME/CFS Project

The CFS/ME Brain Is Inflamed

SURVEY: Cognitive Impairment

Disability Claims and Social Media

Ask the Doctor: What Are Your Favorite Treatments for ME/CFS?

High-Throughput Sequencing of Plasma MicroRNA in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Epigenetics & immune dysfunction in ME/CFS

“End ME/CFS” Mega Chronic Fatigue Syndrome Project Begins

Use of single-nucleotide polymorphisms (SNPs) to distinguish gene expression subtypes of chronic fat...

Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalom...

 
Print Page
Email Article

Acylated ghrelin: A potential marker for fibromyalgia?

  [ 9 votes ]   [ Discuss This Article ]
By D. Homann, et al. • www.ProHealth.com • March 20, 2013


– Source: European Journal of Pain, March 8, 2013

Editor's note:  Acylated ghrelin is the active form of ghrelin, a gastrointestinal hormone which is a strong stimulant of growth hormone from the anterior pituitary. 

Abstract:

BACKGROUND: Fibromyalgia is characterized by chronic widespread pain and sleep disturbances. Overweight and obesity, which lead to metabolic changes, are additional comorbidities that are rarely explored, although they are highly prevalent in patients with fibromyalgia.

METHODS:
We compared the plasma levels of leptin and acylated ghrelin in 17 women with fibromyalgia (patients) and 16 healthy women (controls) with similar age, anthropometric measurements and levels of physical activity. We also investigated the relationships between these two neuropeptides and sleep and various pain characteristics in patients with fibromyalgia. Anthropometric measurements were recorded, and physical activity levels were assessed using a questionnaire. Pain intensity was measured using visual analogue scales (weekly general and mean pain scores). Sleep was assessed using an accelerometry technique.

RESULTS:

  • Compared to the control group, the patient group had increased leptin levels (patients: 22.4 ± 10.6 vs. controls: 13.3 ± 17.9 ng/mL; p < 0.01) and decreased acylated ghrelin levels (patients: 126.7 ± 47.8 vs. controls: 183.3 ± 102.2 pg/mL; p = 0.048).

  • The leptin level was not significantly correlated with any of the variables.

  • Acylated ghrelin level was inversely correlated with the weekly mean pain score (r = -0.67, p < 0.01) and the weekly general pain score (r = -0.67, p < 0.01).

  • Multiple regression analysis revealed that the variations in acylated ghrelin levels accounted for 35% of the weekly general pain and 29% of the weekly mean pain variability.

CONCLUSIONS: These findings indicate that the decreased acylated ghrelin levels in women with fibromyalgia are related to pain intensity.


Source: European Journal of Pain, March 8, 2013. D. Homann, F.M. Louzada, S.M. Góes, S. Roizenblatt, A.L. Lopes, A.R. de Oliveira, N. Leite. Department of Physical Education, Universidade Federal do Paraná, Curitiba, Brazil.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
The Curcumin Revolution: The Curcumin Revolution: "Golden" Ticket to Better Health
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing