ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The New Me

Creating Intimacy Through Mindful Touch When You Live with Chronic Illness

VIDEO: How does your brain respond to pain?

4 Ways to Give Back When You’re Chronically Ill

Millions Missing Day of Protest Draws Attention to Plight of ME/CFS Patients All Over the Globe

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

An Illness Denied for Decades Is Exposed - Lighting Up a Hidden World: CFS and ME

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

SURVEY RESULTS: Weight Management & Chronic Illness

Print Page
Email Article

Acylated ghrelin: A potential marker for fibromyalgia?

  [ 9 votes ]   [ Discuss This Article ]
By D. Homann, et al. • • March 20, 2013

– Source: European Journal of Pain, March 8, 2013

Editor's note:  Acylated ghrelin is the active form of ghrelin, a gastrointestinal hormone which is a strong stimulant of growth hormone from the anterior pituitary. 


BACKGROUND: Fibromyalgia is characterized by chronic widespread pain and sleep disturbances. Overweight and obesity, which lead to metabolic changes, are additional comorbidities that are rarely explored, although they are highly prevalent in patients with fibromyalgia.

We compared the plasma levels of leptin and acylated ghrelin in 17 women with fibromyalgia (patients) and 16 healthy women (controls) with similar age, anthropometric measurements and levels of physical activity. We also investigated the relationships between these two neuropeptides and sleep and various pain characteristics in patients with fibromyalgia. Anthropometric measurements were recorded, and physical activity levels were assessed using a questionnaire. Pain intensity was measured using visual analogue scales (weekly general and mean pain scores). Sleep was assessed using an accelerometry technique.


  • Compared to the control group, the patient group had increased leptin levels (patients: 22.4?±?10.6 vs. controls: 13.3?±?17.9?ng/mL; p?

  • The leptin level was not significantly correlated with any of the variables.

  • Acylated ghrelin level was inversely correlated with the weekly mean pain score (r?=?-0.67, p?

  • Multiple regression analysis revealed that the variations in acylated ghrelin levels accounted for 35% of the weekly general pain and 29% of the weekly mean pain variability.

CONCLUSIONS: These findings indicate that the decreased acylated ghrelin levels in women with fibromyalgia are related to pain intensity.

Source: European Journal of Pain, March 8, 2013. D. Homann, F.M. Louzada, S.M. Góes, S. Roizenblatt, A.L. Lopes, A.R. de Oliveira, N. Leite. Department of Physical Education, Universidade Federal do Paraná, Curitiba, Brazil.

Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria

Natural Remedies

Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map