ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Beginning Again: Living with the Ups and Downs of Life with Chronic Illness

Chronic Christmas: Surviving the Holidays with a Chronic Illness

Productivity Values That Get in the Way of Our Health

Happiness, Gratitude and Appreciation

The “Starvation” Disease? Metabolomics Meets Chronic Fatigue Syndrome Down Under

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

The IACFS/ME 2016 Conference Overviews #1: Energy and Exercise To the Fore

Is Chronic Fatigue Syndrome An Inflammatory Disease? The 2016 IACFS/ME Conference Overviews Pt II

Psychotherapy for ME/CFS Does Not Help Fatigue (much)

Medscape Rocks the IACFS/ME Conference

 
Print Page
Email Article

De Meirleir Study Indicates Possible Autoimmune Process in ME/CFS

  [ 8 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 28, 2013


Editor’s Note: The purpose of this study was to determine if autoimmunity is a factor in some subgroups of patients with ME/CFS. Human endogenous retroviruses, known as HERVs, are ancient retroviruses that are part of the human genome. (They are estimated to comprise about 8% of human DNA.)  Because HERVs are part of our DNA, they do not normally provoke immune reactions. Plasmacytoid dendritic cells (pDCs), which are present in the gut, are a part of the innate immune system. They act to simulate the immune system against antigens. When pDCs react to antibodies against HERV proteins, an underlying autoimmune process may be implicated. Read full article HERE.

Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins. 

~Source: In Vivo. March, 2013.

By K.L. De Meirleir et al.

Abstract

Myalgic encephalomyelitis (ME) is a debilitating illness of unknown etiology characterized by neurocognitive dysfunction, inflammation, immune abnormalities and gastrointestinal distress. An increasing body of evidence suggests that disruptions in the gut may contribute to the induction of neuroinflammation. Therefore, reports of human endogenous retroviral (HERV) expression in association with neuroinflammatory diseases prompted us to investigate the gut of individuals with ME for the presence of HERV proteins. In eight out of 12 individuals with ME, immunoreactivity to HERV proteins was observed in duodenal biopsies. In contrast, no immunoreactivity was detected in any of the eight controls. Immunoreactivity to HERV Gag and Env proteins was uniquely co-localized in hematopoietic cells expressing the C-type lectin receptor CLEC4C (CD303/BDCA2), the co-stimulatory marker CD86 and the class II major histocompatibility complex HLA-DR, consistent with plasmacytoid dendritic cells (pDCs). Although the significance of HERVs present in the pDCs of individuals with ME has yet to be determined, these data raise the possibility of an involvement of pDCs and HERVs in ME pathology. To our knowledge, this report describes the first direct association between pDCs and HERVs in human disease.

Source: In Vivo. 2013 Mar;27(2):177-87. De Meirleir KL, Khaiboullina SF, Frémont M, Hulstaert J, Rizvanov AA, Palotás A, Lombardi VC.





Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Hydroxocobalamin Extreme™ Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Live Without Anxiety or Stress Live Without Anxiety or Stress
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map