ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Study Suggests “Bad Energy” is Core Problem in Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)

Travel Tips for the Chronically Ill

One of Our Strongest Allies Needs Our Help! Please read!

The Genetic Mutation That May Compromise Your Health - And What to Do About It

Getting Clear on Ketogenic Diets (for Fibromyalgia and ME/CFS): A Review

Could we finally have a definitive biomarker for ME/CFS?

Endogenous Pain Facilitation Rather Than Inhibition Differs Between People with Chronic Fatigue Synd...

ME/CFS Research Community Surprises: Submits Ten Research Center Applications to NIH

Making Music – and a Difference – for ME/CFS

The Scientist, the Seahorse and the Nanoneedle – Catching Up with Ron Davis on ME/CFS

 
Print Page
Email Article

Tumor Necrosis Factor-alpha Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation

  [ Not Yet Rated ]   [ 1 Comment ]
By M. Sade-Feldman et al. • www.ProHealth.com • April 6, 2013


Editor's Comment: A number of studies have found elevated inflammatory cytokines in patients with CFS/ME. In 1999, Moss et al. discovered that TNF-a was elevated in CFS patients. Maes et al. confirmed this finding in 2011. Elevated levels of inflammatory cytokines, including TNF-a, have also been found in fibromyalgia patients. (Read the abstract HERE.Zeta chain downregulation has been implicated in cancer and in autoimmune diseases.

~Source: Immunity, Volume 38, Issue 3, 541-554, 07 March 2013

By M. Sade-Feldman et al.

Highlights

  • TNF-a promotes immunosuppression during chronic inflammation via MDSCs
  • TNF-a blocks MDSC maturation by enhancing S100A8/9 and RAGE expression
  • TNF-a augments MDSC suppressive activity impairing T and NK cell function
  • Etanercept enhances MDSC maturation and reduces their suppressive activity

Summary

Elevated concentrations of tumor necrosis factor-a (TNF-a) are detected in pathologies characterized by chronic inflammation. Whether TNF-a plays a role in manipulating the host’s immune system toward generating an immunosuppressive milieu, typical of ongoing chronic inflammation, is unclear. Here we showed that TNF-a exhibited a dual function during chronic inflammation: arresting differentiation of immature myeloid-derived suppressor cells (MDSCs) primarily via the S100A8 and S100A9 inflammatory proteins and their corresponding receptor (RAGE) and augmenting MDSC suppressive activity. These functions led to in vivo T and NK cell dysfunction accompanied by T cell antigen receptor zeta chain downregulation. Furthermore, administration of etanercept (TNF-a antagonist) during early chronic inflammatory stages reduced MDSCs’ suppressive activity and enhanced their maturation into dendritic cells and macrophages, resulting in the restoration of in vivo immune functions and recovery of zeta chain expression. Thus, TNF has a fundamental role in promoting an immunosuppressive environment generated during chronic inflammation.

Source: Immunity, Volume 38, Issue 3, 541-554, 07 March 2013. Sade-Feldman M, Kanterman J, Ish-Shalom E, Elnekave M, Horwitz E, Baniyash M. The Lautenberg Center for General and Tumor Immunology, The Institute for Medical Research Israel-Canada.





Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Hydroxocobalamin Extreme™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

TNF-a
Posted by: IanH
Apr 6, 2013
Also reduces mitochondrial membrane potential gradient when chronically elevated. This in turn leads to many of the symptoms in ME/CFS
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map