ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients

Simmaron’s Spinal Fluid Study Finds Dramatic Differences in Chronic Fatigue Syndrome

5 Lessons I Have Learned Living With Chronic Illness

The Countess of Mar, Medical Politics, and ME/CFS

What were your first symptoms of ME/CFS?

Life for a Young Person with M.E.

Cultivating Self-Compassion

ProHealth's 2014 Advocate of the Year – Ryan Prior

Autoimmune Organization Makes Urgent Call For Fatigue Research

World Famous Joint Relief Formula Enhanced by Modern Science

 
Print Page
Email Article

Two-day Exercise Test Provides Objective Evidence for Post-Exertional Malaise in ME/CFS

  [ 27 votes ]   [ 1 Comment ]
By Christopher R. Snell et al. • www.ProHealth.com • July 8, 2013


Editor's Comment: Post-exertional malaise (PEM) is the hallmark symptom of ME/CFS. Dr. Christopher Snell's group has developed the 2-day Cardiopulmonary Exercise Test (CPET) for ME/CFS, a test that can objectively measure PEM. The CPET is a non-invasive test that has long been used to evaluate cardiac health. By measuring gas exchange (the ratio of oxygen to carbon dioxide), Snell's group has determined that, unlike controls, people with ME/CFS consistently show reduced oxygen consumption. This reseach supports other evidence demonstrating hypoxia (low oxygen levels) in the brains of patients with ME/CFS. It is important to note that the CDC study currently underway does not employ the 2-day CPET as described in this study, but the 1-day CPET, which does not measure PEM. The authors of this study have found the 1-day CPET to be inadequate for distinguishing ME/CFS patients from controls.

Discriminative Validity of Metabolic and Workload Measurements to Identify Individuals With Chronic Fatigue Syndrome

By Christopher R. Snell et al.

Abstract

Objectives:Reduced functional capacity and post-exertional fatigue following physical activity are hallmark symptoms of chronic fatigue syndrome (CFS) and may even qualify for biomarker status. That these symptoms are often delayed may explain the equivocal results for clinical cardiopulmonary exercise testing among individuals with CFS. Test reproducibility in healthy subjects is well documented. This may not be the case with CFS due to delayed recovery symptoms. The objectives for this study was to determine the discriminative validity of objective measurements obtained during CPET to distinguish individuals with CFS from non-disabled sedentary individuals.

Methods:Gas exchange data, workloads and related physiological parameters were compared between 51 individuals with CFS and 10 control subjects, all females, for two maximal exercise tests separated by 24 hours.

Results:Multivariate analysis showed no significant differences between controls and CFS for Test 1. However, for Test 2 the individuals with CFS achieved significantly lower values for oxygen consumption and workload at peak exercise and at the ventilatory/anaerobic threshold. Follow-up classification analysis differentiated between groups with an overall accuracy of 95.1%.

Conclusions:The lack of any significant differences between groups for the first exercise test would appear to support a deconditioning hypothesis for CFS symptoms. However, results from the second test indicate the presence of a CFS related post-exertional fatigue. It might be concluded that a single exercise test is insufficient to reliably demonstrate functional impairment in individuals with CFS. A second test may be necessary to document the atypical recovery response and protracted fatigue possibly unique to CFS, which can severely limit productivity in the home and workplace.

Source: Physical Therapy, 27 June 2013, doi: 10.2522/?ptj.20110368, Christopher R. Snell, Staci R. Stevens, Todd E. Davenport and J. Mark Van Ness. Contact: tdavenport@pacific.edu




Please Discuss This Article:   Post a Comment 

Two day test and PEM
Posted by: Coachme
Jul 19, 2013
The studies done by this group are major for CFS. It is a huge step forward in proving post-exertional malaise. I hope it will help many people with disability tests and help show the validity of this illness. I think it is also good to show that CFS problems with exercise are not deconditioning.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing