Activate Now
 
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Exercise Intolerance in POTS, ME/CFS and Fibromyalgia Explained?

#ISpeakForPain Blitz

5 Ways That I Reduce Stress During Tough Times

Move More: How I Actually Started Exercising with a Chronic Condition

GUIDELINES FOR PAIN WARRIORS

8 Things to Consider for Depression

ACTION ALERT: Improve US chronic pain care

VIDEO: Living with Chronic Pain

Genes Highlight Inflammation and Mast Cells in Fibromyalgia

ME/CFS Flare-ups Caused by Straining Muscles and Nerves

 
Print Page
Email Article

A Specific Proinflammatory Cytokine May Help Assess Functional Status and Disease Serverity of Fibromyalgia Patients

  [ 4 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 4, 2013


Serum levels of high mobility group box 1 protein and its association with quality of life and psychological and functional status in patients with fibromyalgia.

By Pelin Oktayoglu, et al.

Abstract:

AIM: High mobility group box 1 protein (HMGB1) is a proinflammatory cytokine. Previous studies have suggested that HMGB1 can play an important role in the pathogenesis of many rheumatic diseases. The purpose of this study was to investigate the serum levels of HMGB1 in patients with fibromyalgia (FM) and its association with quality of life and psychological and functional status in these patients.

METHODS: Twenty-nine patients who met the 1990 American College of Rheumatology (ACR) criteria for the classification of FM and 29 healthy controls (HC) were included in the present study. Serum samples were collected from both the patients and the HC, and HMGB1 levels were measured by enzyme-linked immunosorbent assay (ELISA). The Fibromyalgia Impact Questionnaire (FIQ) was used to assess the disease severity and functional status in patients with FM. Furthermore, the Nottingham Health Profile was used to assess quality of life in all subjects, as well as the Hospital Anxiety and Depression Scale (HADS) to assess depression and anxiety.

RESULTS: The serum levels of HMGB1 protein were positively correlated with the FIQ scores in patients with FM (P  =  0.002). Mean serum levels of HMGB1 were higher in patients with FM than in HC but this difference was not statistically significant.

CONCLUSION: HMGB1 protein might be a good laboratory-sourced candidate for the assessment of functional status and disease severity in patients with FM.

© 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

Source:  International Journal of Rheumatic Diseases, August 16. 2013. By Pelin Oktayoglu, Mehmet Tahtasiz, Mehtap Bozkurt, Serda Em, Demet Ucar, Levent Yazmalar, Nuriye Mete, Kemal Nas and Orhan Gezer. Departments of Physical Medicine and Rehabilitation, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.





Post a Comment

Featured Products From the ProHealth Store
Hydroxocobalamin Extreme™ Mitochondria Ignite™ with NT Factor® MitoQ®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map