ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

10 Celebrities with ME/CFS

The Brain Boosting and Fatigue Fighting B-12

Severe ME/CFS - New Clinical Study

A New International Newsletter on ME/CFS Is Launched

Norwegian ‘Woulds’ (and ‘Wouldn’ts’): The ME/CFS Survey

Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyeli...

Altered Distribution of Lymphocyte Populations in Chronic Fatigue Syndrome Patients

VIDEO: Julia Newton Talks About Neurocognitive problems in ME/CFS

Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephal...

“Flowers” in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue syn...

 
Print Page
Email Article

Lower frequency of IL-17F sequence variant (His161Arg) in chronic fatigue syndrome patients - Source: Biochemical and Biophysical Research Communications, Sep 4, 2008

  [ 14 votes ]   [ Discuss This Article ]
By Kristine Metzger, Kenny De Meirleir, et al. • www.ProHealth.com • September 10, 2008


Chronic fatigue syndrome (CFS) is characterized by immune dysfunctions including chronic immune activation, inflammation, and alteration of cytokine profiles.

T helper 17 (Th17) cells belong to a recently identified subset of T helper cells, with crucial regulatory function in inflammatory and autoimmune processes. Th17 cells are implicated in allergic inflammation, intestinal diseases, central nervous system inflammation, disorders that may all contribute to the pathophysiology of CFS.

IL-17F is one of the pro-inflammatory cytokines secreted by Th17 cells.

We investigated the association between CFS and the frequency of rs763780, a C/T genetic polymorphism leading to His161Arg substitution in the IL-17F protein. [A polymorphism is a genetic variant that persists in at least 1% of the population.] The His161Arg variant (C allele) antagonizes the pro-inflammatory effects of the wild-type IL-17F.

A significantly lower frequency of the C allele was observed in the CFS population, suggesting that the His161Arg variant may confer protection against the disease.

These results suggest a role of Th17 cells in the pathogenesis of CFS.

Source: Biochemical and Biophysical Research Communications, Sep 4, 2008. [Epub ahead of print] PMID: 18774769, by Metzger K, Frémont M, Roelant C, De Meirleir K. Protea Biopharma, Belgium.

 





Discuss This Article Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness

Natural Remedies

Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Sweet Tips for Fibromyalgia Success Sweet Tips for Fibromyalgia Success
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing