ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

How I Recovered From ME/CFS

The Functional Capacity Evaluation (FCE) and Your Disability Insurance Benefits

HIV, Heart Disease, Diabetes … and Chronic Fatigue Syndrome? The Unutmaz Project to Decode ME/CFS

New Option For Chronic Fatigue Syndrome

Stanford Study Finds Brain Abnormalities in ME/CFS Patients

SURVEY RESULTS: Cognitive Impairment

A Chronic Fatigue Syndrome Brain on Exercise – Not a Pretty Sight

Ask the Doctor: Why is the MTHFR gene important?

How to Jump-start and Sustain Energy Production in CFS

The MTHFR Mutation: Important for CFS-ME? Important for everything?

 
Print Page
Email Article

Hippocampal Metabolite Abnormalities in Fibromyalgia: Correlation with Clinical Features - Source: Journal of Pain, Sep 2, 2008

  [ 5 votes ]   [ Discuss This Article ]
By Patrick B Wood, et al. • www.ProHealth.com • September 10, 2008


Although the pathology of fibromyalgia is poorly understood, a growing body of evidence suggests involvement of the central nervous system. The hippocampus is a brain center that is sensitive to the effects of stress exposure and has been demonstrated to be affected in a variety of disorders whose onset, like fibromyalgia, are associated with stressful experience.

We therefore interrogated the bilateral hippocampus of 16 female fibromyalgia patients in comparison to 8 age- and gender-matched healthy control subjects using single voxel proton magnetic resonance spectroscopy.

• Our results demonstrate a significant reduction in the ratio of N-acetylaspartate to creatine (NAA/Cr) in fibromyalgia patients versus matched control subjects specifically in the right temporal lobe from a voxel centered on the right hippocampus (patient vs control, mean +/- standard deviation: 1.20 +/- 0.13 vs 1.34 +/- 0.10, P = .03).

• Moreover, correlation analysis demonstrated a significant negative correlation between patient scores on the Fibromyalgia Impact Questionnaire and NAA/Cr ratio within the right hippocampus (Spearman rank correlation, rho = -0.681, P = .018).

Our results indicate that fibromyalgia is associated with brain metabolite abnormalities within the right hippocampus that correlate with patient symptoms.

Perspective: We have demonstrated an abnormality in hippocampal brain metabolites in premenopausal female fibromyalgia patients with no psychiatric comorbidity. A significant negative correlation between patient subjective experience of symptoms and a reduced NAA/Cr ratio suggests a role for hippocampal pathology in fibromyalgia.

Source: Journal of Pain, Sep 2, 2008. [Epub ahead of print]  PMID: 18771960, by Wood PB, Ledbetter CR, Glabus Deceased MF, Broadwell LK, Patterson JC 2nd. Departments of Family Medicine, Anesthesiology, Psychiatry, Pharmacology, Toxicology, Neuroscience, and Internal Medicine, LSU Health Sciences Center, Shreveport; PET Imaging Cener, Biomedical Research Institute of NW Louisiana, Shreveport, Louisiana, USA. [E-mail: pwood@anglerbiomedical.com ] Note: part of this research was presented previously at the 2004 World Congress on Myofascial Pain and Fibromyalgia (Munich, Germany) and Human Brain Mapping (Budapest, Hungary).
 




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Immune Support Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing