Activate Now
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Chronic Fatigue Syndrome, Fibromyalgia and Mitchondrial Disorders: A Comparison Plus the MitoQ Trial...

Are All the "Feel-Good" Pathways Blocked in Fibromyalgia and Chronic Fatigue Syndrome?

5 Things I've Learned About Chronic Illness Through Mindfulness

Cellular Havoc: Zeroing In On The Sleep Problems in Fibromyalgia?

Misdiagnosis on a grand scale?

Diagnosing and Managing Mold Exposure

The Pressure We Put Ourselves Under To Find a Way Forward

Strategies for Fighting Depression

Gulf War veterans' health: medical evaluation of a U.S. cohort

The Chokehold Behavioral Treatments Have on Chronic Fatigue Syndrome

Print Page
Email Article

Explaining ME/CFS as immune system’s ‘Pavlov’ response to persistent EBV

  [ 23 votes ]   [ 2 Comments ] • August 10, 2012

Can persistent Epstein-Barr virus infection induce chronic fatigue syndrome as a Pavlov reflex of the immune response?
– Source: Journal of Biological Dynamics, Jan 2012 (final version of record online Jul 16, 2012)

By Elena Agliari, et al.

[Note: To view the free full text of this article proposing a unifying theory of the etiology of chronic fatigue syndrome / myalgic encephalomyelitis (ME/CFS), CLICK HERE. The article includes some intriguing, plain-language background sections and some very complex, formula-heavy statistical sections. The ‘Pavlov’ response refers to how physiological responses can become conditioned to occur without the initial stimulus - e.g., Pavlov's dogs salivating at the sound of a bell that once accompanied feeding time.]

Chronic fatigue syndrome is a protracted illness condition (lasting even years) appearing with strong flu symptoms and systemic defiances by the immune system.

• Here, by means of statistical mechanics techniques, we study the most widely accepted picture for its genesis, namely a persistent acute mononucleosis infection,

• And we show how such infection may drive the immune system towards an out-of-equilibrium metastable state displaying chronic activation of both humoral and cellular responses (a state of full inflammation without a direct 'causes-effect' reason).

By exploiting a bridge with a neural scenario, we mirror killer lymphocytes T(K) and B cells to neurons and helper lymphocytes

[Formula: see text] and [Formula: see text] to synapses, hence showing that the immune system may experience the Pavlov conditional reflex phenomenon:

• If the exposition to a stimulus (Epstein-Barr virus antigens) lasts for too long,

• Strong internal correlations among B cells, killer lymphocyte T(K) and T(H) may develop

• Ultimately resulting in a persistent activation even though the stimulus itself is removed.

These outcomes are corroborated by several experimental findings.

Source: Journal of Biological Dynamics, Mar 2012;6(2):740-62 – full text of record online Jul 16, 2012. PMID:22873615, by Agliari E, Barra A, Vidal KG, Guerra F. Dipartimento di Fisica, Università degli Studi di Parma, Parma, Italy. [Email:]

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® B-12 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

This was disproved in the 1980's
Posted by: spacee
Aug 10, 2012
Dr. Steven Straus was most unhappy for it to be disproved and began cursing when he read
the report.

Yet, I do have hope that we have better testing available in the 21st century. And that some
help for those who need it comes from the testing.
Reply Reply

Good News/Bad News
Posted by: Mikie
Aug 31, 2012
The good news is that if anyone ever finds the mechanism of our immune systems' overreaction to one infection, it may explain how our immune systems overreact to other infections. The bad news is that not everyone with our illnesses had them triggered by the EBV. My own illness was triggered full blown my a mycoplasma infaction. Most of us have had an EBV infection or been exposed to it. It never goes away so it is possible that EBV sets us up for our illnesses; however, I believe there is a genetic factor which might help explain why we overreact to pathogens.

Love, Mikie
Reply Reply
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing