ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

When Retreat Means Advance: A Recovered Chronic Fatigue Syndrome/Fibromyalgia Patient Looks Back

Creating Intimacy Through Mindful Touch When You Live with Chronic Illness

VIDEO: How does your brain respond to pain?

4 Ways to Give Back When You’re Chronically Ill

Factors Associated with Increased Risk for Clinical Insomnia in Patients with Chronic Neck Pain.

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Millions Missing Day of Protest Draws Attention to Plight of ME/CFS Patients All Over the Globe

An Illness Denied for Decades Is Exposed - Lighting Up a Hidden World: CFS and ME

SURVEY RESULTS: Weight Management & Chronic Illness

Print Page
Email Article

Constellation of 5 immune markers - may be diagnostic for post mono ME/CFS

  [ 7 votes ]   [ Discuss This Article ] • September 15, 2012

Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue
- Source: Translational Medicine, Sep 13, 2012

By Gordon Broderick, MD, et al.

[Note: A provisional full text PDF of this article is available at  This study by ME/CFS researchers at clinics in Canada and several US states measured a broad range of cytokines, using uniform laboratory protocols, in patients diagnosed according to uniform criteria, all after infection with the same pathogen (Epstein-Barr) and all still ill at 24 months post infection. Cytokines, produced by the immune system, are involved in the inflammatory response.]

Background: As Chronic Fatigue Syndrome (CFS) has been known to follow Epstein-Bar virus (EBV) and other systemic infections, our objective was to describe differences in immune activation in:

• Post-infective CFS (PI-CFS) patients

• And recovered controls.

We studied 301 adolescents prospectively over 24 months following the diagnosis of monospot-positive infectious mononucleosis (IM).

We found an incidence of CFS at 6, 12 and 24 months of 13%, 7% and 4% respectively.

Methods: Using chemiluminescent imaging we measured the concentrations of IL-1a, 1b, 2, 4, 5, 6, 8, 10, 12 (p70), 13, 15, 17 and 23, IFN-gamma, TNF-alpha and TNF-beta in duplicate plasma samples available in bio-bank from 9 PI-CFS subjects and 12 recovered controls at 24 months post-infection.


Standard comparative analysis indicated significant differences in IL-8 and 23 across subject groups.

In constructing a linear classification model IL-6, 8 and 23 were selected by two different statistical approaches as discriminating features, with IL-1a, IL-2 and IFN-gamma also selected in one model or the other.

This supported an assignment accuracy of better than 80% at a confidence level of 0.95 into PI-CFS versus recovered controls.

Conclusion: These results suggest that co-expression patterns in as few as 5 cytokines associated with Th17 function may hold promise as a tool for the diagnosis of post-infectious CFS.

Source: Translational Medicine, Sep 13, 2012. PMID: 22973830, by Groderick G, Katz BZ, Fernandes H, Fletcher MA, Klimas NG, Smith FA, O’Gorman MRG, Vernon SD, Taylor R. University of Alberta, Edmonton, Alberta, Canada; Children’s Memorial Hospital, Chicago, Illinois; University of Miami, Florida; Miami Veterans Affairs Medical Center, Miami, Florida; Feinberg School of Medicine, Northwestern, Chicago, Illinois; CFIDS Assoc. of America, Charlotte, North Carolina, USA. [Email:]

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Hydroxocobalamin Extreme™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map