ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

Researchers shed new light on cause of Chronic Fatigue Syndrome

May 12 International ME/CFS, Lyme, and FM Awareness Day

Brain abnormalities in ME/CFS

The role of Epstein-Barr virus infection in the development of autoimmune thyroid diseases

Heroes Amidst the Daily Grind of Chronic Illness

Looking After Yourself Isn’t Selfish

Adapting Successfully to Long Term Illness – May Start with Dumping the Denial

Safely Burn Away Body Fat

 
Print Page
Email Article

Are ME/CFS and fibromyalgia tryptophan-associated disorders?

  [ 12 votes ]   [ 1 Comment ]
www.ProHealth.com • October 6, 2012


Article:
A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)
- Source: International Journal of Tryptophan Research, Sep 17, 2012

By Adele Blankfield, BSc

[Note: The full text PDF of this article is available free HERE. It reviews research suggesting that up-regulation of the ‘kynurenine pathway’ may play a role in the clusters of signs and symptoms that predominate in ME/CFS and fibromyalgia patients.

What is the kynurenine pathway? It’s complex, but we located this brief video by biochemist Wesley Hurrell which diagrams the pathway; how its chronic up-regulation may lead to tryptophan and serotonin depletion & produce chronic Th1-immune activation; and the association with symptoms common in ME/CFS and fibromyalgia, including IBS, cognitive impairment, sleep disturbances and depression.]

Abstract:
Last century there was a short burst of interest in the tryptophan-related disorders of pellagra and related abnormalities that are usually presented in infancy.1,2 [L-Tryptophan is an essential amino acid that is a precursor to many neurotransmitters and neurochemicals, including serotonin and melotonin.]

Nutritional physiologists recognized that a severe human dietary deficiency of either tryptophan or the B group vitamins could result in central nervous system (CNS) sequelae such as ataxia [lack of muscle coordination], cognitive dysfunction and dysphoria [anxiety/restlessness], accompanied by skin hyperpigmentation.3,4

The current paper will focus on the emerging role of tryptophan in chronic fatigue syndrome (CFS) and fibromyalgia (FM).

Source: International Journal of Tryptophan Research, Sep 17, 2012; 5, 27-32. DOI: 10.4137/IJTR.S10085, by Blankfield A. Kew, Australia. [Email: gjshnier@bigpond.net.au]




Please Discuss This Article:   Post a Comment 

Problems with tryptophan beyond kynurenine
Posted by: RolfHefti
Oct 7, 2012
The many problems related to kynurenine are just one of the problematic issues with tryptophan.

This research paper seems to insinuate that tryptophan itself isn't a problem (inferred from observed effects of an endogenous tryptophan deficiency), but primarily the chronic release of kynurenines. However, serotonin, for which tryptophan is its precursor, has been shown to be involved in numerous disease conditions, from brain degeneration, cancer, cardiovascular events, and many others (see http://www.supplements-and-health.com/tryptophan-side-effects.html). This doesn't indicate that the loading of tryptophan or serotonin, with drugs or dietary supplements, is biologically desired.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness

Natural Remedies

Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing