ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Crash and Flare Busters for ME/CFS and Fibromyalgia

Letter to My Chronic Illness

Surviving the Holidays with Chronic Fatigue Syndrome and Fibromyalgia. How Do You Do It?

Setting Goals When You Are Chronically Ill

VIDEO: Powerful Proof that Symptoms of Chronic Fatigue Syndrome and Fibromyalgia are REAL and MAINLY...

Is Chronic Fatigue Syndrome (ME/CFS) a Brain Disease? The 2016 IACFS/ME Conference Pt. III

Recovery Potentially Possible: Naviaux Talks on Chronic Fatigue Syndrome (ME/CFS)

Humoral Immunity Profiling of Subjects with Myalgic Encephalomyelitis Using a Random Peptide Microar...

The Great NIH Exercise Initiative: A Boon for Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia?

Dealing with Difficult Landmarks and Anniversaries

 
Print Page
Email Article

Combo of drugs affecting pain different ways helped central sensitization

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 7, 2012


Article:
Duloxetine and Pregabalin for Pain Management in Multiple Rheumatic Diseases Associated with Fibromyalgia
– Source: Pain Practice, Nov 5, 2012 By Chiara Angeletti, MD, et al.

[Note: Duloxetine (Cymbalta) is a serotonin and norepinephrine reuptake inhibitor ('new generation' antidepressant). Pregabalin (Lyrica) is an anticonvulsant. Both are drugs that may be prescribed for fibromyalgia symptoms in the US. Their modes of action are not entirely understood but generally it is thought that duloxetine works on the nerve pathway that inhibits pain, and pregabalin acts on the parts of the nerve that conduct pain signals.]

Abstract: The fibromyalgia syndrome (FMS) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno-rheumatic diseases.

Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by "central sensitization," which is common to many other painful conditions.

The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new-generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome [rheumatic disease involving eye and ear inflammation].

The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin.

Source: Pain Practice (Publication of the World Institute of Pain), Nov 5, 2012. PMID:23126475. Angeletti C, Guetti C, Piroli A, Angeletti PM, Paladini A, Ciccozzi A, Marinangeli F, Varrassi G. Anesthesiology and Pain Medicine, Department of Health Sciences, University of L'Aquila, Italy. [Email: chiara.angeletti@gmail.com]





Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Break Free From Fibromyalgia Break Free From Fibromyalgia

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map