ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Interview: Jennifer Brea Talks About Obstacles, Adjustments, and Inspiration

Post-Exertional Debility is an Important Symptom during Myalgic Encephalomyelitis

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

Models Suggesting Chronic Fatigue Syndrome Is "Amenable to Intervention" Provide Hope: Dr. Broderick...

Burmeister Wins Lawsuit: Court Rules Government Must Produce IOM Documents

Traditional Chinese medicine for chronic fatigue syndrome: A systematic review of randomized clinica...

Is the physical examination normal in CFS?

Symptoms of autonomic dysfunction in chronic fatigue syndrome

Irritable bowel syndrome and chronic fatigue six years after Giardia infection: a controlled prospec...

False Allegations of Child Abuse in Cases of Childhood Myalgic Encephalomyelitis (ME)

 
Print Page
Email Article

Melatonin Plays a Role in Reducing Pain Sensitivity

  [ 39 votes ]   [ 1 Comment ]
www.ProHealth.com • December 7, 2012


Melatonin Plays a Role in Reducing Pain SensitivityArticle:

Melatonin in antinociception: its therapeutic applications. 
– Source: Current Neuropharmacology, June 2012.

By V. Srinivasan, et al.

Abstract:

The intensity of pain sensation exhibits marked day and night variations. Since the intensity of pain perception is low during dark hours of the night when melatonin levels are high, this hormone has been implicated as one of the prime antinociceptive [reducing sensitivity to painful stimuli] substances.

A number of studies have examined the antinociceptive role of melatonin in acute, inflammatory and neuropathic pain animal models.

  • It has been demonstrated that melatonin exerts antinociceptive actions by acting at both spinal cord and supraspinal levels.

  • The mechanism of antinociceptive actions of melatonin involves opioid, benzodiazepine, a(1)- and a(2)-adrenergic, serotonergic and cholinergic receptors.

  • Most importantly however, the involvement of MT(1)/MT(2) melatonergic receptors in the spinal cord has been well documented as an antinociceptive mechanism in a number of animal models of pain perception.

  • Exogenous melatonin [melatonin produced outside the body; i.e., in supplement form] has been used effectively in the management of pain in medical conditions such as fibromyalgia, irritable bowel syndrome and migraine and cluster headache.

  • Melatonin has been tried during surgical operating conditions and has been shown to enhance both preoperative and post-operative analgesia.

The present review discusses the available evidence indicating that melatonin, acting through MT(1)/MT(2) melatonin receptors, plays an important role in the pathophysiological mechanism of pain.

Source: Current Neuropharmacology, June 2012. By V. Srinivasan, E.C. Lauterbach, K.Y. Ho, D. Acuna-Castroviejo, R. Zakaria, A. Brzezinski. Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, 40 Kovai Thirunagar, Coimbatore-641014, Tamilnadu, India.

 




Please Discuss This Article:   Post a Comment 

Melatonin
Posted by: IanH
Dec 8, 2012
The dose of melatonin required for antinociception (painreducingg) is 10mg to 30mg. Some studies have used more than this. Any dosage lower than this has not been shown to be effective. It takes a while to get used to the slight somnolence induced by this dose.

To review this look up the Journal Of Pineal Research. Some of the papers are free to view.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamin B-12

Save on Vitamins and Supplements

Featured Products

5-HTP Extra Strength 200mg 5-HTP Extra Strength 200mg
Increase Serotonin Levels Naturally
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Live Longer: Groundbreaking Research on Omega-3s Live Longer: Groundbreaking Research on Omega-3s
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing