ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Tired of Your Every Night 2 AM Wake-Up Call?

The Challenges of Being a Sick Parent

How to be Broke and Medicated with Fibromyalgia or ME/CFS

Snooze News – The conundrum of sleep deprivation

How Not to Treat Brain Fog

Do you fall asleep easily during the day? Diagnosing and Treating Sleep Apnea

A Biomarker for Chronic Fatigue Syndrome (ME/CFS)? Immunosignature Provides Another Possibility

Migraine Summit Poses Opportunities For Fibromyalgia and Chronic Fatigue Syndrome Patients

12th International IACFS/ME Research and Clinical Conference: Emerging Science and Clinical Care: A ...

Acupuncture and moxibustion for chronic fatigue syndrome in traditional Chinese medicine: a systemat...

 
Print Page
Email Article

Defect in Immune Response Leads to Recurring Bladder Infections

  [ Not Yet Rated ]   [ Discuss This Article ]
www.ProHealth.com • February 20, 2013


Mast Cell Interleukin-10 Drives Localized Tolerance in Chronic Bladder Infection

– Source: Immunity, February 15, 2013

By Cheryl Y. Chan et al.

Highlights

  • MC-dependent immunosuppressive transcriptional program specific to the bladder
  • Local production of IL-10 results in suppressed humoral and cell-mediated responses
  • Multiple MC-deficient mouse models show tissue-specific immunosuppressive role of MC
  • Bladder is a site exhibiting an intrinsic degree of MC-maintained immune privilege

Summary: The lower urinary tract’s virtually inevitable exposure to external microbial pathogens warrants efficient tissue-specialized defenses to maintain sterility. The observation that the bladder can become chronically infected in combination with clinical observations that antibody responses after bladder infections are not detectable suggest defects in the formation of adaptive immunity and immunological memory. We have identified a broadly immunosuppressive transcriptional program specific to the bladder, but not the kidney, during infection of the urinary tract that is dependent on tissue-resident mast cells (MCs). This involves localized production of interleukin-10 and results in suppressed humoral and cell-mediated responses and bacterial persistence. Therefore, in addition to the previously described role of MCs orchestrating the early innate immunity during bladder infection, they subsequently play a tissue-specific immunosuppressive role. These findings may explain the prevalent recurrence of bladder infections and suggest the bladder as a site exhibiting an intrinsic degree of MC-maintained immune privilege.

Source: Immunity, 2013; DOI:10.1016/j.immuni.2012.10.019. Cheryl Y. Chan, Ashley L. St. John, Soman N. Abraham.





Post a Comment

Featured Products From the ProHealth Store
Hydroxocobalamin Extreme™ B-12 Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria

Natural Remedies

The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map