ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Study shows why exercise magnifies exhaustion for chronic fatigue syndrome patients

The Importance of Forgiveness When Living with Chronic Illness

5 Tips for Successfully Changing Your Diet

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

A Commercially Available Probiotic Reduces Chronic Fatigue Syndrome’s Inflammation—Should we offer t...

Evidence in chronic fatigue syndrome for severity-dependent upregulation of prefrontal myelination t...

The experience of sleep in chronic fatigue syndrome: A qualitative interview study with patients

Call to Action: Congressional Hearing on Ampligen

SURVEY RESULTS: What Name Would YOU Choose for CFS?

Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomye...

 
Print Page
Email Article

CoQ10 Supplementation Improves Fibromyalgia Symptoms

  [ 7 votes ]   [ 2 Comments ]
www.ProHealth.com • March 10, 2013


Can Coenzyme Q10 improve clinical and molecular parameter in Fibromyalgia?
– Source: Antioxidants and Redox Signaling, March 4, 2013

By M.D. Cordero, et al.

Abstract:

Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Its pathophysiological mechanisms are difficult to identify and current drug therapies demonstrate limited effectiveness. Both mitochondrial dysfunction and coenzyme Q10 (CoQ10) deficiency have been implicated in FM pathophysiology.

We have investigated the effect of CoQ10 supplementation. We carried out a randomized, double-blind, placebo-controlled trial to evaluate clinical and gene expression effects of forty days of CoQ10 supplementation (300mg/day), in twenty FM patients. This study was registered with controlled-trials.com (ISRCTN 21164124).

  • An important clinical improvement was shown after CoQ10 vs placebo treatment showing a reduction of FIQ [Fibromyalgia Impact Questionnaire] (P<0.001),

  • and a most prominent reduction in pain (P<0.001), fatigue and morning tiredness (P?0.01) subscales from FIQ.

  • Furthermore, we observed an important reduction in pain visual scale (P<0.01)

  • and a reduction in tender points (P<0.01), including recovery of inflammation, antioxidant enzymes, mitochondrial biogenesis and AMPK gene expression levels, associated with phosphorilation of AMPK activity.

These results lead to the hypothesis that CoQ10 have a potential therapeutic effect in FM, and indicate new potential molecular targets for the therapy of this disease. AMPK could be implicated in the pathophysiology of FM.


Source:
Antioxidants and Redox Signaling, March 4, 2013. By M.D. Cordero, E. Alcocer-Gómez, M. de Miguel, O. Culic, A.M. Carrión, J.M. Alvarez-Suarez, P. Bullon, M. Battino, A. Fernández-Rodríguez, J.A. Sánchez-Alcázar. Dpto. Citología e Histología Normal y Patológica, Facultad de Medicina. Universidad de Sevilla, 41009 Sevilla-Spain, Avda. Sánchez-Pizjuán s/n, Sevilla, Spain, 41009, +34 95 4551797 , +34 95 4551799; mdcormor@us.es




Please Discuss This Article:   Post a Comment 

AND
Posted by: IanH
Mar 10, 2013
they used ubiquinone.

This is a great study showing how CoQ10 is as good as or better than any other parmaceutical prescribed for FM.

In our clinic we always use CoQ10 for FM. Working up to 200mg twice daily for three months then decline to 200mg daily thereafter.

When combined with VitB12, Magnesium, MTHF, Creatine Phos and ribose you do get a good result with most people.
Reply Reply

COQ10 dosage
Posted by: Diegolady
Mar 14, 2013
The article doesn't state what dosage they used in the study. I have used COQ10, but never know what dosage to use. Now I will go with the 200 mg daily. Thanks.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria

Natural Remedies

Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing