Activate Now
 
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fibromyalgia: Bad; Fibromyalgia with Migraine: Really Bad

4 Tips for Parenting with Chronic Illness

How Can You Be Positive When You Live With Chronic Pain?

Aching for Pain Relief?

Chocolate's Potential Health Benefits – and its Effect on Chronic Fatigue Syndrome Patients

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

4 Ways to Keep Spirits Up When in Chronic Pain

Finding Your Energy Envelope

The Mystery of Sleep in Fibromyalgia and Chronic Fatigue Syndrome

Did Probiotics Cure My Chronic Fatigue Syndrome?

 
Print Page
Email Article

Enhanced Gene Expression Following Vaccination in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

  [ Not Yet Rated ]   [ 1 Comment ]
By Ekua W. Brenu et al. • www.ProHealth.com • April 4, 2013


Editors Comment: The underlying hypothesis of this pilot study was that flu vaccine could act as an immune stimulator at the genetic level, thereby correcting the predominant immune abnormality found in CFS/ME. The researchers found that after flu vaccination there was, indeed, an increase in cytotoxic activity. That is, the immune system, at least for a short time, was more efficient at producing antibodies. Athough the authors concluded that "these effects may be beneficial as they may cause a significant improvement in mechanisms such as cytotoxic activity," many CFS/ME patients have reported that flu vaccine makes them feel much worse. The full version of the study can be accessed from the link below. 

~Source: IJCM. March, 2013. 

By Ekua W. Brenu et al.

Abstract

Vaccines have been shown to cause differential expression of genes and increase antibody titers against antigens.   Influenza vaccines may have an effect on unexplained disorders such as Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Immunological changes have been identified following immunization with trivalent influenza vaccine (TIV). The objective of this pilot study was to examine the consequences of TIV on cytokine and cytotoxic genes in CFS/ME. Peripheral blood mononuclear cells were preferentially isolated from whole blood of 7 CFS/ME  patients and 8 controls. Following total RNA extraction and synthesis of cDNA, reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) was used to determine the expression levels of mRNAs for cytotoxic genes (perforin (PRF1), granzyme A (GZMA), granzyme B (GZMB) and cytokine genes. GZMB was significantly increased overall in the CFS/ME patients compared to the controls. GZMA was significantly increased 28 days after vaccination while PRF1 was reduced prevaccination but increased 14 days post-vaccination in the CFS/ME patients. There were no significant changes in cytokine genes pre or post vaccination. Administration of TIV may increase the expression of lytic genes in CFS/ME and this may contribute to the increase in cytotoxic activity we observed in these patients post vaccination.

SourceIJCM. Vol. 4 No. 3, March, 2013.  Ekua W. Brenu, Gunn M. Atkinson, Mieke L. van Driel, Sanne Kreijkamp-Kaspers, Don R. Staines, Sonya M. Marshall-Gradisnik





Post a Comment

Featured Products From the ProHealth Store
MitoQ® Ultra ATP+, Double Strength Hydroxocobalamin Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Increase in Granzyme B
Posted by: IanH
Apr 4, 2013
Is most likely to make patients feel worse even though it is enhancing NKcell performance and reduction of infection.

Is it not?
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

How Glutathione Can Save Your Life

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood

FIBROMYALGIA
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
LYME DISEASE
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
FORUMS
Fibromyalgia
M.E. & CFS
Lyme Disease
General Health
WHOLESALE
AFFILIATES GUARANTEE
PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing