ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
 
Print Page
Email Article

Norepinephrine Reuptake Inhibitors Have Negative Effect on Postural Tachycardia Syndrome (POTS)

  [ 5 votes ]   [ 1 Comment ]
www.ProHealth.com • September 5, 2013

previous article next article

Editor's comment:  Postural Tachycardia Syndrome (POTS), a form of orthostatic intolerance, often occurs with fibromyalgia and ME/CFS.  Since serotonin and norepinephrine reuptake inhibitors like Cymbalta and Savella are frequently prescribed for fibromyalgia, it is important to know that they may worsen POTS symptoms. 

Note: You may read the full text of this article free HERE.

Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome.

By Elizabeth A. Green, et al.

Abstract:

BACKGROUND:
Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inhibit the norepinephrine reuptake transporter (NRI). NRI medications can increase sympathetic nervous system tone, which may increase heart rate (HR) and worsen symptoms in POTS patients. We sought to determine whether NRI with atomoxetine increases standing tachycardia or worsens the symptom burden in POTS patients.

METHODS AND RESULTS:
Patients with POTS (n=27) underwent an acute drug trial of atomoxetine 40 mg and placebo on separate mornings in a randomized, crossover design. Blood pressure (BP), HR, and symptoms were assessed while seated and after standing prior to and hourly for 4 hours following study drug administration.

  • Atomoxetine significantly increased standing HR compared with placebo (121±17 beats per minute versus 105±15 beats per minute; P=0.001) in POTS patients, with a trend toward higher standing systolic BP (P=0.072).

  • Symptom scores worsened with atomoxetine compared to placebo (+4.2 au versus -3.5 au; P=0.028) from baseline to 2 hours after study drug administration.

CONCLUSION: Norepinephrine reuptake inhibition with atomoxetine acutely increased standing HR and symptom burden in patients with POTS.

Source: Journal of the American Heart Association, September 3, 2013. By Elizabeth A. Green, Beng; Vidya Raj, MB, ChB; Cyndya A. Shibao, MD, MSCI; Italo Biaggioni, MD; Bonnie K. Black, RN, CNP; William D. Dupont, PhD; David Robertson, MD; Satish R. Raj, MD, MSC. Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN.


previous article
  Rating 4.8 (5 votes) next article




DISCUSS THIS ARTICLE   (1 existing comment) Post a Comment 


Serotonin Norepinephrine reuptake inhibitors (SNRI's)
Posted by: cmesmile
Sep 24, 2013
I am just curious if SNRI's would also have the same effect on POTS symptoms? I am on Effexor XR and have been diagnosed with POTS and CFIDS. I have not noticed any major issues, but have not been on it that long. Does anyone have info on SNRI's?
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Ubiquinol CoQ-10 Ubiquinol CoQ-10
Reduced, Active Form of CoQ10
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Fatigued to Fantastic!™ Energy Revitalization System - Berry Splash Fatigued to Fantastic!™ Energy Revitalization System - Berry Splash
Vitality, Health and Lasting Energy
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Phosphatidyl Serine Phosphatidyl Serine
Sharpen memory and mental acuity

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

FREE: Stop Feeding Yourself PAIN Guide [more]

Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel sy... [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing