ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

The Muscle-Brain Connection in ME/CFS Revealed

The Neurobiology of ME/CFS

Interview: Jennifer Brea Talks About Obstacles, Adjustments, and Inspiration

DNA Methylation Modifications Associated with Chronic Fatigue Syndrome

Adrenal Burnout? Naturally Boost Your Energy & Manage Stress

Smartphone app and specialised clinic for chronic fatigue patients

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

Post-Exertional Debility is an Important Symptom during Myalgic Encephalomyelitis

VIDEO: Dr. Newton Talks About Biomarkers and the Future of ME/CFS Treatment

Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigu...

 
Print Page
Email Article

Immune system discovery could lead to EBV vaccine to prevent mono, some cancers

  [ 4 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 15, 2013


Editor's Comment: This study has bearing on ME/CFS, an illness which was originally thought to be caused by Epstein-Barr virus (EBV). Here the researchers discovered that EBV turns off key proteins that make the virus-infected cells visible to natural killer cells (NK cells). The lower the NK cell function, the greater the increase in EBV-infected cells. Low NK cell function is a common finding among ME/CFS patients, as are high viral titers of EBV.

Press Release: Child and Family Research Institute, October 11, 2013

Development of a vaccine against Epstein-Barr virus (EBV) has taken a step forward with the Canadian discovery of how EBV infection evades detection by the immune system. 

EBV causes infectious mononucleosis and cancers such as Hodgkin’s lymphoma and nasopharyngeal carcinoma, which is the most common cancer in China, as well as opportunistic cancers in people with weakened immune systems. A member of the herpes virus family that remains in the body for life, the virus infects epithelial cells in the throat and immune cells called B cells.

The researchers discovered that the virus triggers molecular events that turn off key proteins, making infected cells invisible to the natural killer T (NKT) immune cells that seek and destroy EBV-infected cells. 

“If you can force these invisible proteins to be expressed, then you can render infected cells visible to NKT cells, and defeat the virus. This could be key to making a vaccine that would provide immunity from ever being infected with EBV,” says Dr. Rusung Tan, the study’s principal investigator. Dr. Tan is a scientist and director of the Immunity in Health & Disease research group at the Child & Family Research Institute at BC Children’s Hospital, and a professor in the Department of Pathology at the University of British Columbia.

The findings were published this week in the print edition of the scientific journal Blood.

For this study, the researchers looked at cells from infected tonsils that had been removed from patients at BC Children’s Hospital by Dr. Frederick Kozak. The researchers infected the tonsillar B cells with EBV, and then combined some of these cells with NKT cells. They found that more NKT cells led to fewer EBV-infected cells, while an absence of NKT cells was associated with an increase in EBV-infected cells.


This research was funded by the Canadian Institutes of Health Research SLED Team for Childhood Autoimmunity, and BC Children’s Hospital Foundation. Dr. Tan is a Michael Smith Foundation Senior Scholar.



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
A Breakthrough for Mitochondrial Dysfunction A Breakthrough for Mitochondrial Dysfunction
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing