Activate Now
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Alcohol intolerance in CFS - gives us a clue as to the mechanisms of fatigue

The "Mind Diet" Reduces the Risk Of Alzheimer’s Dementia. Might It Also Help the Brain Fog Found Wit...

Simplifying Nutritional Support in CFS & Fibromyalgia

Need Help with Pain Management? There's an App for That

How Walking to Bathroom Can Be Harder Than Running a Marathon: A Doctor’s ME/CFS Case Study

Ask the Doctor: Is CFS an onset to fibromyalgia? What is the difference?

How Multiple Chronic Illnesses Shaped One Woman Into a Patient Advocate

Fighting Fatigue with Ground-breaking French Oak Wood Extract

Is Your Body Your Friend and Healing Ally?

Birds of a Feather: The Joys of Community

Print Page
Email Article

PQQ Reduces Inflammation, Improves Mitochondrial-Related Metabolism in Humans

  [ 16 votes ]   [ 1 Comment ] • January 25, 2014

PQQ Reduces Inflammation, Improves Mitochondrial-Related Metabolism in Humans
Reprinted with kind permission of Life Extension, January 2014.

Studies described in the December 2013 issue of The Journal of Nutritional Biochemistry add evidence to a benefit for pyrroloquinoline quinone (PQQ), a compound that activates factors involved in the regulation of cellular energy metabolism and mitochondria formation, in reducing inflammation and enhancing mitochondrial function. (Mitochondria are the cells' energy-producing organelles.)

In their introduction to the article, Calliandra B. Harris and colleagues from the University of California, Davis observe that the reduced form of PQQ is a potent antioxidant. "It is also noteworthy that there may have been a constant exposure to PQQ-like compounds throughout biological evolution based on the observations that stellar dust contains PQQ-like compounds," they remark.

Dr Harris and associates note that while the mechanisms of PQQ in energy-related metabolism and neurologic functions in animals have been explored, its mechanisms of action in humans had not been confirmed.

In one study, five men and five women ingested a single dose of PQQ and changes in antioxidant potential were measured in plasma samples collected over the following 48 hours. A decrease in plasma thiobarbituric acid reactive products (TBARS) was observed over time, indicating a reduction in oxidative stress in comparison with presupplementation levels.

In a second study, PQQ was administered daily for three days. Blood samples obtained before and after treatment were analyzed for markers of inflammation and a number of metabolites were measured in urinary samples obtained during the same time points. A significant decline in post-treatment C-reactive protein and interleukin-6 levels occurred indicating a decrease in the inflammatory response. The researchers also documented alterations in urinary metabolites that indicated improvements in mitochondrial efficiency.

"The data reported are among the first to link systemic effects of PQQ in animals to related or corresponding effects in humans," the authors announce. "The data herein support the hypothesis that human subjects respond rapidly to PQQ supplementation with changes in urinary metabolites consistent with enhanced mitochondria related functions."

For more information about PQQ, see “Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing


These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.

Please Discuss This Article:   Post a Comment 

Posted by: IanH
Jan 29, 2014
Anything which helps the function and integrity of mitochondria and oxidative phosphorylation will help both Fibromyalgia and M.E.

These illnesses are cellular energetics diseases. Almost all symptoms can be explained by energetics (low ATP synthesis).
Reply Reply
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements for ME/CFS Support

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing