Activate Now
 
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Neuroinflammation Man: Jarred Younger on Inflammation, Fibromyalgia and Chronic Fatigue Syndrome

Riding the Chronic Illness Roller Coaster

Coenzyme Q10 (CoQ10) for Fibromyalgia, ME/CFS and Migraine

Dear Dr. Collins: I’m Disabled. Can the N.I.H. Spare a Few Dimes?

Finding Joy in Every Day

SURVEY RESULTS: What Triggered Your Illness?

7 Things I Have Learned From Having a Chronic Illness

Underlying Keys to Recovery and Overcoming Obstacles

Rituximab – Promising Effects

CONFERENCE REPORT: Invest in ME 10th Annual Conference, 2015

 
Print Page
Email Article

Lower frequency of IL-17F sequence variant (His161Arg) in chronic fatigue syndrome patients - Source: Biochemical and Biophysical Research Communications, Sep 4, 2008

  [ 14 votes ]   [ Discuss This Article ]
By Kristine Metzger, Kenny De Meirleir, et al. • www.ProHealth.com • September 10, 2008


Chronic fatigue syndrome (CFS) is characterized by immune dysfunctions including chronic immune activation, inflammation, and alteration of cytokine profiles.

T helper 17 (Th17) cells belong to a recently identified subset of T helper cells, with crucial regulatory function in inflammatory and autoimmune processes. Th17 cells are implicated in allergic inflammation, intestinal diseases, central nervous system inflammation, disorders that may all contribute to the pathophysiology of CFS.

IL-17F is one of the pro-inflammatory cytokines secreted by Th17 cells.

We investigated the association between CFS and the frequency of rs763780, a C/T genetic polymorphism leading to His161Arg substitution in the IL-17F protein. [A polymorphism is a genetic variant that persists in at least 1% of the population.] The His161Arg variant (C allele) antagonizes the pro-inflammatory effects of the wild-type IL-17F.

A significantly lower frequency of the C allele was observed in the CFS population, suggesting that the His161Arg variant may confer protection against the disease.

These results suggest a role of Th17 cells in the pathogenesis of CFS.

Source: Biochemical and Biophysical Research Communications, Sep 4, 2008. [Epub ahead of print] PMID: 18774769, by Metzger K, Frémont M, Roelant C, De Meirleir K. Protea Biopharma, Belgium




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Live Without Anxiety or Stress
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing