ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Study shows why exercise magnifies exhaustion for chronic fatigue syndrome patients

The Importance of Forgiveness When Living with Chronic Illness

5 Tips for Successfully Changing Your Diet

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

A Commercially Available Probiotic Reduces Chronic Fatigue Syndrome’s Inflammation—Should we offer t...

The experience of sleep in chronic fatigue syndrome: A qualitative interview study with patients

The Countess of Mar, Medical Politics, and ME/CFS

Call to Action: Congressional Hearing on Ampligen

SURVEY RESULTS: What Name Would YOU Choose for CFS?

Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomye...

 
Print Page
Email Article

Lower frequency of IL-17F sequence variant (His161Arg) in chronic fatigue syndrome patients - Source: Biochemical and Biophysical Research Communications, Sep 4, 2008

  [ 14 votes ]   [ Discuss This Article ]
By Kristine Metzger, Kenny De Meirleir, et al. • www.ProHealth.com • September 10, 2008


Chronic fatigue syndrome (CFS) is characterized by immune dysfunctions including chronic immune activation, inflammation, and alteration of cytokine profiles.

T helper 17 (Th17) cells belong to a recently identified subset of T helper cells, with crucial regulatory function in inflammatory and autoimmune processes. Th17 cells are implicated in allergic inflammation, intestinal diseases, central nervous system inflammation, disorders that may all contribute to the pathophysiology of CFS.

IL-17F is one of the pro-inflammatory cytokines secreted by Th17 cells.

We investigated the association between CFS and the frequency of rs763780, a C/T genetic polymorphism leading to His161Arg substitution in the IL-17F protein. [A polymorphism is a genetic variant that persists in at least 1% of the population.] The His161Arg variant (C allele) antagonizes the pro-inflammatory effects of the wild-type IL-17F.

A significantly lower frequency of the C allele was observed in the CFS population, suggesting that the His161Arg variant may confer protection against the disease.

These results suggest a role of Th17 cells in the pathogenesis of CFS.

Source: Biochemical and Biophysical Research Communications, Sep 4, 2008. [Epub ahead of print] PMID: 18774769, by Metzger K, Frémont M, Roelant C, De Meirleir K. Protea Biopharma, Belgium.

 




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing