ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

The Muscle-Brain Connection in ME/CFS Revealed

The Neurobiology of ME/CFS

Interview: Jennifer Brea Talks About Obstacles, Adjustments, and Inspiration

Adrenal Burnout? Naturally Boost Your Energy & Manage Stress

DNA Methylation Modifications Associated with Chronic Fatigue Syndrome

Smartphone app and specialised clinic for chronic fatigue patients

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

VIDEO: Dr. Newton Talks About Biomarkers and the Future of ME/CFS Treatment

Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigu...

Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology

 
Print Page
Email Article

Neuroendocrine and immune network re-modeling in chronic fatigue syndrome: An exploratory analysis – Source: Genomics, Sep 4, 2008

  [ 66 votes ]   [ Discuss This Article ]
By Jim Fuite, Suzanne D. Vernon, Gordon Broderick • www.ProHealth.com • September 10, 2008


This work investigates the significance of changes in association patterns linking indicators of neuroendocrine and immune activity in patients with chronic fatigue syndrome (CFS).

Gene sets preferentially expressed in specific immune cell isolates were integrated with neuroendocrine data from a large population-based study.

Co-expression patterns linking immune cell activity with hypothalamic-pituitary-adrenal (HPA), thyroidal (HPT) and gonadal (HPG) axis status were computed using mutual information criteria.

Networks in control and CFS subjects were compared globally in terms of a weighted graph edit distance. Local re-modeling of node connectivity was quantified by node degree and eigenvector centrality measures.

Results indicate statistically significant differences between CFS and control networks determined mainly by re-modeling around pituitary and thyroid nodes as well as an emergent immune sub-network.

Findings align with known mechanisms of chronic inflammation and support possible immune-mediated loss of thyroid function in CFS exacerbated by blunted HPA axis responsiveness.

Source: Genomics, Sep 4, 2008. [E-pub ahead of print]. PMID: 18775774, by Fuite J, Vernon SD, Broderick G. The Chronic Fatigue and Immune Dystunction Syndromes (CFIDS) Association of America, Charlotte, NC, USA (Dr. Vernon); Department of Medicine, Division of Pulmonary Faculty of Medicine and Dentistry University of Alberta; Walter Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada. [E-mail: gordon.broderick@ualberta.ca]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria

Natural Remedies

Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing