ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

The Muscle-Brain Connection in ME/CFS Revealed

The Neurobiology of ME/CFS

Interview: Jennifer Brea Talks About Obstacles, Adjustments, and Inspiration

Adrenal Burnout? Naturally Boost Your Energy & Manage Stress

DNA Methylation Modifications Associated with Chronic Fatigue Syndrome

Smartphone app and specialised clinic for chronic fatigue patients

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

VIDEO: Dr. Newton Talks About Biomarkers and the Future of ME/CFS Treatment

Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigu...

Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology

 
Print Page
Email Article

Growth hormone treatment for sustained pain reduction and improvement in quality of life in severe fibromyalgia - Source: Pain, Mar 30, 2012

  [ 10 votes ]   [ 1 Comment ]
By Guillem Cuatrecasas, et al. • www.ProHealth.com • April 5, 2012


[Note: Insulin-like growth factor 1 (growth hormone) helps maintain muscle tissue. Most growth hormones are secreted during the deep sleep cycle, so it is important to reach this restorative sleep phase for healthy levels of IGF-1. Recent research indicating sodium oxybate (Xyrem) may help fibromyalgia symptoms could be owing to an ability to stimulate release of growth hormone. See for example “Sodium oxybate for the treatment of fibromyalgia,” Jun 16, 2011, by Roland Staud at the University of Florida.]

Functional defects in growth hormone (GH) secretion and its efficacy as a complementary treatment have been suggested for fibromyalgia.

This study investigated the efficacy and safety of low-dose GH as an add-on therapy in patients with both severe FM and low insulin-like growth factor 1 levels.

A total of 120 patients were enrolled in a multicenter, placebo-controlled study for 18 months.

• They were randomly assigned to receive either 0.006mg/kg/day of GH subcutaneously (group A, n=60) or placebo (group B, n=60) for 6 months (blind phase).

• The placebo arm was switched to GH treatment from month 6 to month 12 (open phase),

• And a follow-up period after GH discontinuation was performed until month 18.

Standard treatment for fibromyalgia (selective serotonin re-uptake inhibitors, opioids, and amitriptyline) was maintained throughout the study.

Number and intensity of tender points, Fibromyalgia Impact Questionnaire (FIQ) with its subscales, and EuroQol 5 dimensions test (EQ5D) with visual analog [pain] scale (VAS) were assessed at different time points. At the end of the study [6 months after therapy ended]:

• 53% of group A patients [who received GH for 12 months] obtained fewer than 11 positive tender points, vs 33% of group B patients [who received GH from months 7 -12] (P<.05).

• 39.1% vs 22.4% reached more than 50% improvement in VAS (P<.05). [The VAS pain scale measures pain by color, descriptions, and numbers 1-10, from 'none' (0) to 'agonizing' (10).]

• Group A patients showed significantly improved FIQ scores (P=.01) compared with group B.

Although GH discontinuation worsened all scores in both groups during follow-up, impairment in pain perception was less pronounced in the GH-treated group [who received it for 12 months](P=.05).

In this largest and longest placebo-controlled trial performed in FM (NCT00933686), addition of GH to the standard treatment is effective in reducing pain, showing sustained action over time.

Source: Pain, Mar 30, 2012. Cuatrecasas G, Alegre C, Fernandez-Solà J, Gonzalez MJ, Garcia-Fructuoso F, Poca-Dias V, Nadal A, Cuatrecasas G, Navarro F, Mera A, Lage M, Peinó R, Casanueva F, Liñan C, Sesmilo G, Coves MJ, Izquierdo JP, Alvarez I, Granados E, Puig-Domingo M. Endocrinology Department Centro Médico Teknon and Clinica Sagrada Familia, Barcelona, Spain.
 




Please Discuss This Article:   Post a Comment 

Cost/Benefit
Posted by: KerryK
Apr 5, 2012
The benefits of GH in this study appear to be modest, as is true of the other option. However, I understand that GH is very expensive so it is hard to imagine that it could ever be a common treatment.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing