ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

The Cheney Protocol for Chronic Fatigue Syndrome

Is the physical examination normal in CFS?

Traditional Chinese medicine for chronic fatigue syndrome: A systematic review of randomized clinica...

Burmeister Wins Lawsuit: Court Rules Government Must Produce IOM Documents

Symptoms of autonomic dysfunction in chronic fatigue syndrome

Your Rights When a Disability Claim is Terminated

From Our Readers: Comments & Suggestions – 9/10/14

Overcoming the barriers to the diagnosis and management of chronic fatigue syndrome/ME in primary ca...

Is The Physical Examination Normal in CFS? Part 2: Joint Hypermobility

Treating Immune Dysfunction in ME/CFS

 
Print Page
Email Article

Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes – Source: Gut, Jul 5, 2012

  [ 6 votes ]   [ Discuss This Article ]
By Patrick A Hughes, et al. • www.ProHealth.com • July 11, 2012


[Note: Though the full text of this article is fee-based, two web-only Data Supplement files - "Materials" and "Methods" - may be accessed here. ]

Objective: The gut is a major site of contact between immune and sensory systems and evidence suggests that patients with irritable bowel syndrome (IBS) have immune dysfunction.

Here we show how this dysfunction differs between major IBS subgroups and how immunocytes communicate with sensory nerves. [Immunocytes are different white blood cell types that participate in the body’s inflammatory & immune responses to protect against infection and repair injured tissues. Unlike red blood cells they have a nucleus.]

Design: Peripheral blood mononuclear cell supernatants [clear fluid at the top of blood sample after centrifuging] from 20 diarrhea predominant IBS (D-IBS) patients, 15 constipation predominant IBS (C-IBS) patients and 36 healthy subjects were applied to mouse colonic sensory nerves, and effects on mechanosensitivity [nerve sensitivity to movement] assessed.

Cytokine/chemokine concentration in the supernatants was assessed by proteomic analysis and correlated with abdominal symptoms, and expression of cytokine receptors evaluated in colonic dorsal root ganglia neurons. We then determined the effects of specific cytokines on colonic afferents.

[Cytokines act as molecular messengers between cells, usually regulating various inflammatory responses. Afferent neurons are nerve pathways that carry impulses from the stimulus receptor site/sense organ through the nervous system toward the brain. Efferent neurons communicate in the opposite direction.]

Results:

• D-IBS supernatants caused mechanical hypersensitivity of mouse colonic afferent endings, which was reduced by infliximab. [Infliximab, aka Remicade, is an antibody that blocks the inflammation-promoting cytokine TNF-alpha and is used to treat (reduce inflammation in) autoimmune diseases such as Crohn’s disease and RA.]

• C-IBS supernatants did not, but occasionally elevated basal discharge [neuron activity].

• Supernatants of healthy subjects inhibited afferent mechanosensitivity via an opioidergic [suppressing perception of pain] mechanism.

Several cytokines were elevated in IBS supernatants, and levels correlated with pain frequency and intensity in patients. Visceral afferents expressed receptors for four cytokines:

• IL-1beta,

• IL-6,

• IL-10 and

• TNF-alpha.

TNF-alpha most effectively caused mechanical hypersensitivity which was blocked by a transient receptor potential channel TRPA1 antagonist. [TRPA1 is one of the many types of ion channels located on cell membranes. It serves as a sensor/communicator. A TRPA1 antagonist would reduce TRPA1 sensitivity.]

IL-1beta elevated basal firing, and this was lost after tetrodotoxin blockade of sodium channels. [IL-1 beta induces pro-inflammatory COX-2 in the central nervous system, contributing to inflammatory pain hypersensitivity. Tetrodotoxin quells neuron activity.]

Conclusions:

Distinct patterns of immune dysfunction and interaction with sensory pathways occur in different patient groups and through different intracellular pathways.

Our results indicate IBS patient subgroups would benefit from selective targeting of the immune system.

Source: Gut, Jul 5, 2012. DOI:10.1136/gutjnl-2011-301856, by Hughes PA, Harrington AM, Castro J, Liebregts T, Adam B, Grasby DJ, Isaacs NJ, Maldeniya L, Martin CM, Persson J, Andrews JM, Holtmann G, Blackshaw AL, Brierley SM. Nerve-Gut Research Laboratory, Discipline of Medicine and Discipline of Physiology, Faculty of Health Sciences, The University of Adelaide; Department of Gastroenterology and Hepatology, Royal Adelaide Hospital; and Department of Leukocyte Biology, Women's and Children's Health Research Institute, Women's and Children's Hospital, Adelaide, South Australia, Australia; Department of Bone Marrow Transplantation, University Hospital Essen, West German Cancer Centre, Germany; Neurogastroenterology Group, Blizard Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK. [Email: patrick.hughes@adelaide.edu.au]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Free Shipping on Nutritional Supplement Orders

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Live Longer: Groundbreaking Research on Omega-3s Live Longer: Groundbreaking Research on Omega-3s
A Breakthrough for Mitochondrial Dysfunction A Breakthrough for Mitochondrial Dysfunction
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing