ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Beginning Again: Living with the Ups and Downs of Life with Chronic Illness

Chronic Christmas: Surviving the Holidays with a Chronic Illness

Productivity Values That Get in the Way of Our Health

Happiness, Gratitude and Appreciation

10 Questions to Ask Yourself Before Saying Yes

The “Starvation” Disease? Metabolomics Meets Chronic Fatigue Syndrome Down Under

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

The IACFS/ME 2016 Conference Overviews #1: Energy and Exercise To the Fore

Is Chronic Fatigue Syndrome An Inflammatory Disease? The 2016 IACFS/ME Conference Overviews Pt II

Psychotherapy for ME/CFS Does Not Help Fatigue (much)

 
Print Page
Email Article

CoQ10 supports reversal of statin-caused mitochondrial dysfunction, energy drain

  [ 19 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 11, 2012


Article:
Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance
- Source: Journal of Applied Physiology, May 31, 2012

By A Muraki, K Miyashita, et al.

[Note: Atorvastatin, aka Lipitor, is a lipophilic statin, meaning it dissolves in & is attracted to lipids (fats). Prevastatin, aka Pravachol, is a hydrophilic statin, meaning it dissolves in water, and so is believed to have less muscle penetration than lipophilic statins.]

Abstract:
Background: Statins are cholesterol-lowering drugs widely used in the prevention of cardiovascular diseases; however, they are associated with various types of myopathies.

Statins inhibit HMG-CoA reductase and thus decrease biosynthesis of low-density lipoprotein cholesterol and may also reduce ubiquinones, essential coenzymes of a mitochondrial electron transport chain, which contain isoprenoid residues, synthesized through an HMG-CoA reductase-dependent pathway.

Therefore, we hypothesized that statin treatment might influence physical performance:

• Through muscular mitochondrial dysfunction

• Due to ubiquinone deficiency.

Methods and Results:

The effect of two statins, atorvastatin and pravastatin, on ubiquinone content, mitochondrial function and physical performance was examined by using statin-treated mice.

Changes in energy metabolism in association with statin-treatment were studied by using cultured myocytes.

We found that atorvastatin-treated mice developed:

• Muscular mitochondrial dysfunction due to ubiquinone deficiency,

• And a decrease in exercise endurance,

• Without affecting muscle mass and strength.

Meanwhile, pravastatin at 10 times higher dose [than] atorvastatin had no such effects.

In cultured myocytes, atorvastatin-related decrease in mitochondrial activity led to:

• A decrease in oxygen utilization

• And an increase in lactate production.

Conversely, coenzyme Q10 treatment in atorvastatin-treated mice:

• Reversed atorvastatin-related mitochondrial dysfunction

• And a decrease in oxygen utilization,

• And thus improved exercise endurance.

Conclusion:

Atorvastatin decreased exercise endurance in mice through mitochondrial dysfunction due to ubiquinone deficiency.

Ubiquinone supplementation with coenzyme Q10 could reverse atorvastatin-related mitochondrial dysfunction and decrease in exercise tolerance.

Source: Journal of Applied Physiology, May 31, 2012. DOI:10.1152/japplphysiol.01362 by Muraki A, Miyashita K, Mitsuishi M, Tamaki M, Tanaka K, Itoh H. Keio University School of Medicine, Minato, Tokyo, Japan. [Email: miyakaza2sc.itc.keio.ac.jp]





Post a Comment

Featured Products From the ProHealth Store
MitoQ® Mitochondria Ignite™ with NT Factor® Hydroxocobalamin Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map