Activate Now
 
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 tips for cooking and cleaning your kitchen when you’re chronically ill

When the Joy Just Isn’t Getting Through

20 Date Night Ideas for Chronic Illness

The New Dual Activation Pain Relief Cream

Microstructural Havoc: The Immune System, Fatigue and the Brain - An ME/CFS and FM Scenario

Next Gen Opioid Drugs Promise Pain Relief Without Side Effects

Ketamine: Wonder Drug?

What You Need to Know About How Your Tasty “Bliss Point” Affects Your Chronic Illness

SURVEY RESULTS: Medical Marijuana

The Stanford Chronic Pain Self-Management Program

 
Print Page
Email Article

Low vitamin D & EBV immune activity may be key to MS breakthrough within 2–3 years: German research

  [ 59 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 19, 2012


Article:
Low vitamin D and elevated immunoreactivity against Epstein-Barr virus before first clinical manifestation of multiple sclerosis
– Source: Journal of Neurology, Neurosurgery and Psychiatry, Aug 11, 2012

By Brenard F Decard, Andrew Chan, et al.

[Apparently pre-onset blood donations provided this insight, underscored by the finding that the MS patients' average vitamin D levels had dropped another 50% by the time of diagnosis.]

Abstract:
Objective:
Vitamin D deficiency and Epstein-Barr virus (EBV) infection may be associated with the development of multiple sclerosis (MS).

We investigated serum 25-hydroxyvitamin D (25-OH-D) levels and anti-EBV immunoreactivity in 25 individuals before the first clinical manifestation of MS.

Patients and methods:

• 56 serum samples of 25 individuals who had donated blood prior to the first clinical MS manifestation (clinically isolated syndrome (CIS))

• Four male subjects, 21 female subjects,

• Mean age 31.5 years at time of pre-CIS blood sampling;

• Mean age at disease onset 33.4 years…

….were available, covering an interval of 7.3 years-2 months (mean 31.5 months) before CIS.

In 18 of 25 patients serum samples were also obtained after established diagnosis of MS.

Longitudinal age- and gender-matched healthy blood donors (four male subjects, 21 female subjects, 39 samples, mean age 32.5 years) served as controls.

Serum 25-OH-D was measured by isotope dilution-liquid chromatography-tandem mass spectrometry. 25-OH-D levels were deconvoluted using published seasonal coefficients from a German population.

Immunoglobulin G (IgG) against Epstein-Barr virus nuclear antigen-1 (EBNA1) were assessed using commercially available ELISA.

Results:

• Low 25-OH-D levels were observed during the 24-month pre-CIS interval (47.8 (32.5-77.2) nmol/l, median (IQR); healthy controls: 81.6 (57.7-98.5), p=0.004,

• However, still higher than after established diagnosis (24.5 (13.7-47.7), p<0 .0001) compared with controls).

• IgG against EBNA1 during the 36-month pre-CIS interval was increased (185.9 (91.2–460.0) IU/ml, median (IQR); healthy controls 63.7 (29.5–121.6), p=0.002).

Conclusions: Low vitamin D and remote EBV infection may be associated with clinical MS breakthrough within 2–3 years.

Source: Journal of Neurology, Neurosurgery and Psychiatry, Aug 11, 2012. PMID:22888143, by Décard BF, von Ahsen N, Grunwald T, Streit F, Stroet A, Niggemeier P, Schottstedt V, Riggert J, Gold R, Chan A.Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum; Department of Neurology, St. Josef-Hospital, and Department of Molecular and Medical Virology, Ruhr-University Bochum; Department of Clinical Chemistry, University Medical Center Göttingen; German Red Cross Blood Transfusion Service West, Central Laboratory, Hagen; Department of Transfusion Medicine, University of Göttingen, Germany. [E-mail: andrew.chan@rub.de]





Post a Comment

Featured Products From the ProHealth Store
MitoQ® Mitochondria Ignite™ with NT Factor® Hydroxocobalamin Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Aching for Pain Relief?

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map