ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Unravelling the Mysteries of ME/CFS and Fibromyalgia: Meet the Man Behind the Book

How Myofascial Release Got Me Back On My Feet Again

16 Tips from 16 Years Sick

NIH announces centers for myalgic encephalomyelitis/chronic fatigue syndrome research

Cort Johnson Interviews ME/CFS Victor Martha Kilcoyne

Caregivers Draw Support By Mapping Their Relationships

Pediatric Chronic Pain: Prevalence, economic impact, and its relevance to the current opioid epidemi...

Ten Years with ME. This One May Take the Cake

How Physical Therapists are Getting it About Chronic Fatigue Syndrome (ME/CFS)

Three NIH Funded ME/CFS Research Centers….and (What Else?) a Controversy

 
Print Page
Email Article

Low vitamin D & EBV immune activity may be key to MS breakthrough within 2–3 years: German research

  [ 59 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 19, 2012


Article:
Low vitamin D and elevated immunoreactivity against Epstein-Barr virus before first clinical manifestation of multiple sclerosis
– Source: Journal of Neurology, Neurosurgery and Psychiatry, Aug 11, 2012

By Brenard F Decard, Andrew Chan, et al.

[Apparently pre-onset blood donations provided this insight, underscored by the finding that the MS patients' average vitamin D levels had dropped another 50% by the time of diagnosis.]

Abstract:
Objective:
Vitamin D deficiency and Epstein-Barr virus (EBV) infection may be associated with the development of multiple sclerosis (MS).

We investigated serum 25-hydroxyvitamin D (25-OH-D) levels and anti-EBV immunoreactivity in 25 individuals before the first clinical manifestation of MS.

Patients and methods:

• 56 serum samples of 25 individuals who had donated blood prior to the first clinical MS manifestation (clinically isolated syndrome (CIS))

• Four male subjects, 21 female subjects,

• Mean age 31.5 years at time of pre-CIS blood sampling;

• Mean age at disease onset 33.4 years…

….were available, covering an interval of 7.3 years-2 months (mean 31.5 months) before CIS.

In 18 of 25 patients serum samples were also obtained after established diagnosis of MS.

Longitudinal age- and gender-matched healthy blood donors (four male subjects, 21 female subjects, 39 samples, mean age 32.5 years) served as controls.

Serum 25-OH-D was measured by isotope dilution-liquid chromatography-tandem mass spectrometry. 25-OH-D levels were deconvoluted using published seasonal coefficients from a German population.

Immunoglobulin G (IgG) against Epstein-Barr virus nuclear antigen-1 (EBNA1) were assessed using commercially available ELISA.

Results:

• Low 25-OH-D levels were observed during the 24-month pre-CIS interval (47.8 (32.5-77.2) nmol/l, median (IQR); healthy controls: 81.6 (57.7-98.5), p=0.004,

• However, still higher than after established diagnosis (24.5 (13.7-47.7), p<0 .0001) compared with controls).

• IgG against EBNA1 during the 36-month pre-CIS interval was increased (185.9 (91.2–460.0) IU/ml, median (IQR); healthy controls 63.7 (29.5–121.6), p=0.002).

Conclusions: Low vitamin D and remote EBV infection may be associated with clinical MS breakthrough within 2–3 years.

Source: Journal of Neurology, Neurosurgery and Psychiatry, Aug 11, 2012. PMID:22888143, by Décard BF, von Ahsen N, Grunwald T, Streit F, Stroet A, Niggemeier P, Schottstedt V, Riggert J, Gold R, Chan A.Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum; Department of Neurology, St. Josef-Hospital, and Department of Molecular and Medical Virology, Ruhr-University Bochum; Department of Clinical Chemistry, University Medical Center Göttingen; German Red Cross Blood Transfusion Service West, Central Laboratory, Hagen; Department of Transfusion Medicine, University of Göttingen, Germany. [E-mail: andrew.chan@rub.de]





Post a Comment

Featured Products From the ProHealth Store
MitoQ® Energy NADH™ 12.5mg B-12 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map