Activate Now
 
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 tips for cooking and cleaning your kitchen when you’re chronically ill

Chronic Illness: You Don’t Get It Until You Get It

3 Natural Sleep Remedies That May Surprise You

20 Date Night Ideas for Chronic Illness

When the Joy Just Isn’t Getting Through

The New Dual Activation Pain Relief Cream

Microstructural Havoc: The Immune System, Fatigue and the Brain - An ME/CFS and FM Scenario

Physically and Mentally Exhausted? How to Restore Energy at Its Source

Next Gen Opioid Drugs Promise Pain Relief Without Side Effects

VIDEO: Tired But Wired

 
Print Page
Email Article

Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

  [ 1 vote ]   [ Discuss This Article ]
By Ekua W Benu, Sonya M Marshall-Gradisnik, et al. • www.ProHealth.com • October 9, 2012


[Note: microRNAs (miRNAs) are biological regulators of cell function [see video]. Aberrant expression of microRNAs has been implicated in numerous disease states, with the result that investigations to identify, understand and potentially manipulate them represent a cutting-edge field of research.]

Background: Immune dysfunction associated with a disease often has a molecular basis.

A novel group of molecules known as microRNAs (miRNAs) have been associated with suppression of translational processes involved in cellular development and proliferation, protein secretion, apoptosis, immune function and inflammatory processes.

MicroRNAs may be implicated in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), where immune function is impaired.

The objective of this study was to determine the association between miRNAs in cytotoxic cells and CFS/ME. ['Cytotoxic' denotes 'cell-killing'.]

Methods:

Natural Killer (NK) and CD8(+)T cells were preferentially isolated from peripheral blood mononuclear cells from all participants (CFS/ME, n = 28; mean age = 41.8 +/- 9.6 years; and controls, n = 28; mean age = 45.3 +/- 11.7 years), via negative cell enrichment.

Following total RNA extraction and subsequent synthesis of cDNA, reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) was used to determine the expression levels of nineteen miRNAs.

Results:

• There was a significant reduction in the expression levels of miR-21, in both the NK and CD8(+)T cells in the CFS/ME sufferers.

• Additionally, the expression of miR-17-5p, miR-10a, miR-103, miR-152, miR-146a, miR-106, miR-223 and miR-191 was significantly decreased in NK cells of CFS/ME patients in comparison to the non-fatigued controls.

Limitations: The results from these investigations are not yet transferable into the clinical setting, further validatory studies are now required.

Conclusions:

• Collectively these miRNAs have been associated with apoptosis, cell cycle, development and immune function.

• Changes in miRNAs in cytotoxic cells may reduce the functional capacity of these cells and disrupt effective cytotoxic activity along with other immune functions in CFS/ME patients.

Source: Journal of Affective Disorders, May 7, 2012 [fee-based article]. PMID:22572093, by Brenu EW, Ashton KJ, van Driel M, Staines DR, Peterson D, Atkinson GM, Marshall-Gradisnik SM. Faculty of Health Science and Medicine, Population Health and Neuroimmunology Unit, Bond University, Robina, Queensland, Australia. [Email: ekbrenu@bond.edu.au]





Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Aching for Pain Relief?

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map