ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Profound, debilitating fatigue found to be a major issue for autoimmune disease patients in new nati...

Chronic fatigue syndrome and fibromyalgia in diagnosed sleep disorders: a further test of the ‘unita...

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

May 12 International ME/CFS, Lyme, and FM Awareness Day

A Missing Subset in ME/CFS and Fibromyalgia Revealed? Take the Disease Course Survey

Heroes Amidst the Daily Grind of Chronic Illness

The role of Epstein-Barr virus infection in the development of autoimmune thyroid diseases

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

Looking After Yourself Isn’t Selfish

Adapting Successfully to Long Term Illness – May Start with Dumping the Denial

 
Print Page
Email Article

Evidence that heightened pain perception in CFS is linked to oxidative stress

  [ 6 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 10, 2012


Article:
Modulation of the Axon-Reflex Response to Local Heat by Reactive Oxygen Species (ROS) in subjects with Chronic Fatigue Syndrome
- Source: Journal of Applied Physiology, Nov 8, 2012

By Marvin S Medow, PhD, et al.

[Note: Dr. Medow's research specialties include CFS, orthostatic dysfunction, nutrition, and cellular structure & function. Reactive oxygen species (ROS) are reactive molecules/free radicals – unstable molecules lacking an oxygen atom that are a byproduct of mitochondrial energy production. If not recycled by antioxidants, such as glutathione (which are able to donate a stabilizing oxgen atom to them without themselves becoming unstable), ROS steal oxygen atoms from other molecules in the cell, which in turn are unstabilized, and so on, creating a cell damaging chain reaction. This state is called “oxidative stress.”]

Abstract:
Local cutaneous heating causes vasodilation as an initial first peak, a nadir, and increase to plateau. Reactive oxygen species (ROS) modulate the heat plateau in healthy controls. The initial peak, due to C-fibre nociceptor-mediated axon reflexes, is blunted with local anesthetics, and may serve as a surrogate for the cutaneous response to peripheral heat.

Chronic Fatigue Syndrome (CFS) subjects report increased perception of pain.

To determine the role of ROS in this neurally-mediated response, we evaluated changes in cutaneous blood flow from local heat in 9 CFS subjects (16-22 years) compared to 8 healthy controls (18-26 years).

We heated skin to 42°C and measured local blood flow as a percentage of maximum cutaneous vascular conductance (%CVC(max)).

While CFS subjects had significantly lower baseline flow (8.75+/-0.56 vs. 12.27+/-1.07 (%CVC(max) , CFS vs. control)), there were no differences between groups to local heat.

We then re-measured this with apocynin to inhibit NADPH oxidase, allopurinol to inhibit xanthine oxidase, tempol to inhibit superoxide, and ebselen to reduce H(2)O(2).

Apocynin significantly increased baseline blood flow (before heat, 14.91+/-2.21 vs. 8.75+/-1.66) and the first heat peak (69.33+/-3.36 vs. 59.75+/-2.75).

Allopurinol and ebselen only enhanced the first heat peaks (71.55+/-2.48 vs. 61.72+/-2.01 and 76.55+/-5.21 vs. 58.56+/-3.66, respectively).

Tempol had no effect on local heating.

None of these agents changed the response to local heat in control subjects.

Thus the response to heat may be altered by local levels of ROS, particularly H(2)O(2) [hydrogen peroxide] in CFS subjects, and may be related to their hyperesthesia/ hyperalgesia [abnormally increased sensitivity/pain perception].

Source: Journal of Applied Physiology, Nov 8, 2012. PMID:23139367, by Medow MS, Aggarwal A, Baugham IL, Messer ZR, Stewart JM. New York Medical College, Valhalla, New York, USA. [Email: marvin_medow@nymc.edu]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

How Glutathione Can Save Your Life How Glutathione Can Save Your Life
World Famous Joint Relief Formula Enhanced by Modern Science World Famous Joint Relief Formula Enhanced by Modern Science
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing