ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The New Me

Creating Intimacy Through Mindful Touch When You Live with Chronic Illness

VIDEO: How does your brain respond to pain?

4 Ways to Give Back When You’re Chronically Ill

Millions Missing Day of Protest Draws Attention to Plight of ME/CFS Patients All Over the Globe

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

An Illness Denied for Decades Is Exposed - Lighting Up a Hidden World: CFS and ME

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

SURVEY RESULTS: Weight Management & Chronic Illness

Print Page
Email Article

CFS Patients with POTS: Clinically Distinct Subgroup

  [ 448 votes ]   [ Discuss This Article ] • December 6, 2012

Clinical characteristics of a novel subgroup of chronic fatigue syndrome patients with postural orthostatic tachycardia syndrome
– Source: Journal of Internal Medicine, Dec 4, 2012

By I Lewis, J Newton, et al.

[Note: POTS is one of five types of orthostatic intolerance that collectively affect nearly all chronic fatigue syndrome (ME/CFS) patients, according to Dr. David Bell - see “Orthostatic Intolerance and Chronic Fatigue Syndrome.”]

Objectives: A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them from CFS patients without POTS in terms of clinical and autonomic features.

Methods: A total of 179 patients with CFS (1994 Centers for Disease Control and Prevention criteria) attending one of the largest Department of Health-funded CFS clinical services were included in the study.

Outcome measures were:

1. Symptom assessment tools including the fatigue impact scale, Chalder fatigue scale, Epworth sleepiness scale (ESS), orthostatic grading scale (OGS) and hospital anxiety and depression scale (HADS-A and -D, respectively),

2. Autonomic function analysis including heart rate variability and

3. Hemodynamic responses including left ventricular ejection time and systolic blood pressure drop upon standing.


CFS patients with POTS (13%, n=24) were:

• Younger (29 +/- 12 vs. 42 +/- 13 years, P<0.0001) [probability the difference resulted by chance less than 1 in 10,000],

• Less fatigued (Chalder fatigue scale, 8 +/- 4 vs. 10 +/- 2, P=0.002),

• Less depressed (HADS-D, 6 +/- 4 vs. 9 +/- 4, P=0.01),

• And had reduced daytime hypersomnolence [hypersomnolence is excessive sleeping/sleepiness] (ESS, 7 +/- 6 vs. 10 +/- 5, P=0.02)…

…Compared with patients without POTS.

In addition, they exhibited greater orthostatic intolerance (OGS, 11 +/- 5; P<0.0001) and autonomic dysfunction.

A combined clinical assessment tool of Epworth sleepiness scale 9 or less and orthostatic grading scale 9 or more identifies accurately CFS patients with POTS with 100% positive and negative predictive values.


The presence of POTS marks a distinct clinical group of CFS patents, with phenotypic features differentiating them from those without POTS.

A combination of validated clinical assessment tools can determine which CFS patients have POTS with a high degree of accuracy, and thus potentially identify those who require further investigation and consideration for therapy to control heart rate.

Source: Journal of Internal Medicine, Dec 4, 2012. PMID:23206180, by Lewis I, Pairman J, Spickett G, Newton JL. Institute for Ageing & Health, Newcastle University, Newcastle, UK. [Email:]

Post a Comment

Featured Products From the ProHealth Store
MitoQ® Mitochondria Ignite™ with NT Factor® Hydroxocobalamin Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map