ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Twenty-Six Years of Hell: An ME/CFS/FM Recovery Story

What Makes You Forget?

Motivation: It's Not What You Think

The Opioid Painkiller Clampdown – Will it Lead to Better Drugs?

Top 10 Gifts to People Living with Pain

An Alternative to Goals and Resolutions: Intentions and Extreme Permissiveness

Could Chronic Fatigue Syndrome (ME/CFS) Be a Chronic Form of Sepsis?

Chronic Fatigue Syndrome (ME/CFS) Researcher and Patients Shine During NIH Call

Unrest Flies High, Dr. Oz Talks ME/CFS and Ms Magazine Delivers

Urgency: Ron Davis and His (Non-NIH Funded) ME/CFS Collaborative Research Center

 
Print Page
Email Article

Lower Levels of ATP and PCr Found in Muscles of Fibromyalgia Patients

  [ 20 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 7, 2013


[Note:  ATP stands for adenosine triphosphate, which is described as the energy currency of life.  Mitochondria are the energy producers in each cell and they supply this energy in the form of ATP.  PCr stands for phosphocreatinine, an organic compound found in muscle tissue that stores and provides energy for muscular contraction.]

Article:

Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients - A (31) P-MRS study.

– Source: European Journal of Pain, January 30, 2013

by G. Gerdle, et al.

Abstract:

BACKGROUND AND METHODS: Fibromyalgia (FMS) has a prevalence of approximately 2% in the population. Central alterations have been described in FMS, but there is not consensus with respect to the role of peripheral factors for the maintenance of FMS.

( 31) P Magnetic Resonance Spectroscopy ((31) P-MRS) has been used to investigate the metabolism of phosphagens in muscles of FMS patients, but the results in the literature are not in consensus. The aim was to investigate the quantitative content of phosphagens and pH in resting quadriceps muscle of patients with FMS (n?=?19) and in healthy controls (Controls; n?=?14) using (31) P-MRS. It was also investigated whether the concentrations of these substances correlated with measures of pain and/or physical capacity.

RESULTS:

  • Significantly lower concentrations of adenosine triphosphate (ATP) and phosphocreatinine (PCr; 28-29% lower) were found in FMS.

  • No significant group differences existed with respect to inorganic phosphate (Pi), Pi/PCr and pH.

  • The quadriceps muscle fat content was significantly higher in FMS than in Controls [FMS: 9.0?±?0.5% vs. Controls: 6.6?±?0.6%; (mean?±?standard error); P?=?0.005].

  • FMS had significantly lower hand and leg capacity according to specific physical test, but there were no group differences in body mass index, subjective activity level and in aerobic fitness.

  • In FMS, the specific physical capacity in the leg and the hand correlated positively with the concentrations of ATP and PCr; no significant correlations were found with pain intensities.

CONCLUSIONS: Alterations in intramuscular ATP, PCr and fat content in FMS probably reflect a combination of inactivity related to pain and dysfunction of muscle mitochondria.


Source: European Journal of Pain, January 30, 2013. B. Gerdle, M.F. Forsgren, A. Bengtsson, O.D. Leinhard, B. Soren, A. Karlsson, V. Brandejsky, E. Lund, P. Lundberg.  Rehabilitation Medicine, Department of Medicine and Health Sciences (IMH), Faculty of Health Sciences, Linköping University, Sweden; Pain and Rehabilitation Centre, UHL, Linköping, Sweden.





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg B-12 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria

Natural Remedies

Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map