Activate Now
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Misdiagnosis on a grand scale?

Myalgic encephalomyelitis, chronic fatigue syndrome: An infectious disease

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Are All the "Feel-Good" Pathways Blocked in Fibromyalgia and Chronic Fatigue Syndrome?

Chronic Fatigue Syndrome, Fibromyalgia and Mitchondrial Disorders: A Comparison Plus the MitoQ Trial...

5 Things I've Learned About Chronic Illness Through Mindfulness

An assessment of fatigue in patients with postural orthostatic tachycardia syndrome

Increased Vulnerability to Pattern-Related Visual Stress in Myalgic Encephalomyelitis

Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR ...

NIH takes action to bolster research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Print Page
Email Article

Cymbalta vs. Lyrica: Medical Costs and Medication Compliance Among Fibromyalgia Patients

  [ 3 votes ]   [ Discuss This Article ] • March 26, 2013

Editor's Note: This study compares both total medical costs and medication compliance among fibromyalgia patients who began taking either duloxetine (Cymbalta) or pregabalin (Lyrica) during the year 2008.  At that time, milnacipran (Savella) had not yet been approved for treating FM. 

Direct Medical Costs and Medication Compliance among Fibromyalgia Patients: Duloxetine Initiators vs. Pregabalin Initiators.
– Source: Pain Practice, March 14, 2013

By P. Sun, et al.


OBJECTIVES: To assess and compare direct medical costs and medication compliance between patients with fibromyalgia who initiated duloxetine and patients with fibromyalgia who initiated pregabalin in 2008.

A retrospective cohort study design was used based on a large US national commercial claims database (2006 to 2009). Patients with fibromyalgia aged 18 to 64 who initiated duloxetine or pregabalin in 2008 and who had continuous health insurance 1 year preceding and 1 year following the initiation were selected into duloxetine cohort or pregabalin cohort based on their initiated agent.

Medication compliance was measured by total supply days, medication possession ratio (MPR), and proportion of patients with MPR  ?  0.8. Direct medical costs were measured by annual costs per patient and compared between the cohorts in the year following the initiation. Propensity score stratification and bootstrapping methods were used to adjust for distribution bias, as well as cross-cohort differences in demographic, clinical and economic characteristics, and medication history prior to the initiation.

RESULTS: Both the duloxetine (n  =  3,033) and pregabalin (n  =  4,838) cohorts had a mean initiation age around 49  years, 89% were women.

During the postindex year, compared to the pregabalin cohort, the duloxetine cohort had

  • higher totally annual supply days (273.5 vs. 176.6, P  <  0.05),

  • higher MPR (0.7 vs. 0.5, P  <  0.05),

  • and more patients with MPR  ?  0.8 (45.1% vs. 29.4%, P  <  0.05).

Further, relative to pregabalin cohort, duloxetine cohort had

  • lower inpatient costs ($2,994.9 vs. $4,949.6, P  <  0.05),

  • lower outpatient costs ($8,259.6 vs. $10,312.2, P  <  0.05),

  • similar medication costs ($5,214.6 vs. $5,290.8, P  >  0.05),

  • and lower total medical costs ($16,469.1 vs. $20,552.6, P  <  0.05) in the postinitiation year.

CONCLUSIONS: In a real-world setting, patients with fibromyalgia who initiated duloxetine in 2008 had better medication compliance and consumed less inpatient, outpatient, and total medical costs than those who initiated pregabalin.

Source: Pain Practice, March 14, 2013. By P. Sun, X. Peng, S. Sun, D. Novick, D.E. Faries, J.S. Andrews, M.M. Wohlreich, and A. Wu. Kailo Research Group, Indianapolis, IN, U.S.A.

Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength B-12 Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria

Natural Remedies

Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Live Without Anxiety or Stress
Natural Relief for Soreness, Pain and Swelling – Putting Out the Fire
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
"It's Not Easy Being Green" - But It Is Healthy

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing