ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Not Just an "Ill Person" - Ways to expand your identity when you're chronically ill

Is Poor Sleep Pummeling the Immune System in ME/CFS and Fibromyalgia? A Vicious Circle Examined

Taking a Moment

Glial Cell Inhibitors: The Next Sleep Drugs for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)?

Staying Connected with Friends While Ill

VIDEO: Illness and Isolation

Inflammation correlates with symptoms in chronic fatigue syndrome

Call Out the Imbalance in Current Policy Making for Pain Management and Prescription Opioid Use

The Secret to Chronic Happiness as You Age

Molecular Underpinnings of ME/CFS Explored at the Open Medicine Foundation Symposium

 
Print Page
Email Article

Enhanced Gene Expression Following Vaccination in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

  [ Not Yet Rated ]   [ 1 Comment ]
By Ekua W. Brenu et al. • www.ProHealth.com • April 4, 2013


Editors Comment: The underlying hypothesis of this pilot study was that flu vaccine could act as an immune stimulator at the genetic level, thereby correcting the predominant immune abnormality found in CFS/ME. The researchers found that after flu vaccination there was, indeed, an increase in cytotoxic activity. That is, the immune system, at least for a short time, was more efficient at producing antibodies. Athough the authors concluded that "these effects may be beneficial as they may cause a significant improvement in mechanisms such as cytotoxic activity," many CFS/ME patients have reported that flu vaccine makes them feel much worse. The full version of the study can be accessed from the link below. 

~Source: IJCM. March, 2013. 

By Ekua W. Brenu et al.

Abstract

Vaccines have been shown to cause differential expression of genes and increase antibody titers against antigens.   Influenza vaccines may have an effect on unexplained disorders such as Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Immunological changes have been identified following immunization with trivalent influenza vaccine (TIV). The objective of this pilot study was to examine the consequences of TIV on cytokine and cytotoxic genes in CFS/ME. Peripheral blood mononuclear cells were preferentially isolated from whole blood of 7 CFS/ME  patients and 8 controls. Following total RNA extraction and synthesis of cDNA, reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) was used to determine the expression levels of mRNAs for cytotoxic genes (perforin (PRF1), granzyme A (GZMA), granzyme B (GZMB) and cytokine genes. GZMB was significantly increased overall in the CFS/ME patients compared to the controls. GZMA was significantly increased 28 days after vaccination while PRF1 was reduced prevaccination but increased 14 days post-vaccination in the CFS/ME patients. There were no significant changes in cytokine genes pre or post vaccination. Administration of TIV may increase the expression of lytic genes in CFS/ME and this may contribute to the increase in cytotoxic activity we observed in these patients post vaccination.

SourceIJCM. Vol. 4 No. 3, March, 2013.  Ekua W. Brenu, Gunn M. Atkinson, Mieke L. van Driel, Sanne Kreijkamp-Kaspers, Don R. Staines, Sonya M. Marshall-Gradisnik





Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ MitoQ® Energy NADH™ 12.5mg


Article Comments Post a Comment

Increase in Granzyme B
Posted by: IanH
Apr 4, 2013
Is most likely to make patients feel worse even though it is enhancing NKcell performance and reduction of infection.

Is it not?
Reply Reply
 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map