ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Exercise Tests Suggest Autoimmunity Causes the Exertion Problems in Chronic Fatigue Syndrome, Fibrom...

Not Just an "Ill Person" - Ways to expand your identity when you're chronically ill

Is Poor Sleep Pummeling the Immune System in ME/CFS and Fibromyalgia? A Vicious Circle Examined

Is Chronic Fatigue Real?

Taking a Moment

VIDEO: Illness and Isolation

Staying Connected with Friends While Ill

Inflammation correlates with symptoms in chronic fatigue syndrome

Recognizing the Needs of Pain Patients in Substance Use Policy

Call Out the Imbalance in Current Policy Making for Pain Management and Prescription Opioid Use

 
Print Page
Email Article

Carnosine Improves Cognitive Function in Gulf War Illness, Implications for CFS/ME

  [ 7 votes ]   [ 1 Comment ]
www.ProHealth.com • April 28, 2013


Editor's Comment: Carnosine, a dipeptide composed of the amino acids histidine and beta-alanine, is found abundantly in muscle and brain tissue. A number of studies have found that carnosine is a potent free-radical scavenger, and can mitigate against the damaging effects of aldehydes created by the peroxidation of cell membrane fatty acids (oxidative stress). Because roughly 50% of the brain is fat, carnosine may have significant benefits for people with neurological impairments caused by oxidative stress. Dr. Paul Cheney, Dr. Martin Pall, and others, have cited evidence of increased peroxidation of cell membrane fatty acids among patients with CFS/ME. It is noteworthy that the veterans who participated in this study also met the criteria for CFS/ME.

Note: The full article can be accessed from the abstract.

Carnosine Treatment for Gulf War Illness: A Randomized Controlled Trial

By James N. Baraniuk et al.

Abstract

About 25% of 1990-1991 Persian Gulf War veterans experience disabling fatigue, widespread pain, and cognitive dysfunction termed Gulf War illness (GWI) or Chronic Multisymptom Illness (CMI). A leading theory proposes that wartime exposures initiated prolonged production of reactive oxygen species (ROS) and central nervous system injury. The endogenous antioxidant L-carnosine (B-alanyl-L-histidine) is a potential treatment since it is a free radical scavenger in nervous tissue. To determine if nutritional supplementation with L-carnosine would significantly improve pain, cognition and fatigue in GWI, a randomized double blind placebo controlled 12 week dose escalation study involving 25 GWI subjects was employed. 

L-carnosine was given as 500, 1000, and 1500 mg increasing at 4 week intervals. Outcomes included subjective fatigue, pain and psychosocial questionnaires, and instantaneous fatigue and activity levels recorded by ActiWatch Score devices. Cognitive function was evaluated by WAIS-R digit symbol substitution test. 

Carnosine had 2 potentially beneficial effects: WAIS-R scores increased significantly, and there was a decrease in diarrhea associated with irritable bowel syndrome. No other significant incremental changes were found. Therefore, 12 weeks of carnosine (1500 mg) may have beneficial cognitive effects in GWI. Fatigue, pain, hyperalgesia, activity and other outcomes were resistant to treatment.

Source: Journal of Health Science; Vol. 5, No. 3; 2013. James N. Baraniuk, Suliman El-Amin, Rebecca Corey, Rakib U. Rayhan & Christian R. Timbol.





Post a Comment

Featured Products From the ProHealth Store
MitoQ® Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®


Article Comments Post a Comment

add the following
Posted by: IanH
Apr 28, 2013
B12 and CoQ10 to the carnosine and you will getter better results
For longer term improvements add vitamin D3 with B12 and CoQ10

I have tested several people after treatment with B12+CoQ10+Carnosine for a range of cognitive functions using the 3MS, after treatment with B12+CoQ10+Carnosine which is a wider range test than the Wais.

Results are mixed but significant. Not enough subjects to do a report though.
Reply Reply
 
Optimized Curcumin Longvida with Omega-3

Featured Products

MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map