ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

The Muscle-Brain Connection in ME/CFS Revealed

The Neurobiology of ME/CFS

P2P: The Question They Will Not Ask

Interview: Jennifer Brea Talks About Obstacles, Adjustments, and Inspiration

Adrenal Burnout? Naturally Boost Your Energy & Manage Stress

Smartphone app and specialised clinic for chronic fatigue patients

DNA Methylation Modifications Associated with Chronic Fatigue Syndrome

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

VIDEO: Dr. Newton Talks About Biomarkers and the Future of ME/CFS Treatment

Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigu...

 
Print Page
Email Article

Resveratrol Inhibits Allergic Reactions in Mice

  [ 1 vote ]   [ Discuss This Article ]
www.ProHealth.com • June 7, 2013


Editor's Note: Resveratrol, a compound found in grapes and other plants, has been widely studied for its therapeutic effects, including the reduction of oxidative stress, weight loss,and anti-tumor  as well as anti-inflammatory and anti-microbial effects. 

Resveratrol Inhibits IgE-Mediated Basophilic Mast Cell Degranulation and Passive Cutaneous Anaphylaxis in Mice

By Seon-Young Han et al.

Abstract

Resveratrol is a phytoalexin abundantly found in red grape skin and is effective in antitumor and antiinflammation associated with immune responses. This study investigated whether resveratrol suppressed immunoglobulin (Ig)E-mediated allergic responses and passive cutaneous anaphylaxis (PCA) in rat RBL-2H3 mast cells and in BALB/c mice.

The release of B-hexosaminidase and histamine was enhanced in mast cells sensitized with anti-dinitrophenyl (DNP)-IgE and subsequently stimulated by DNP-human serum albumin (HSA), indicative of mast cell degranulation. When mast cells were pretreated with nontoxic resveratrol at 1–25 umol/L, such induction was dose dependently diminished. Spleen tyrosine kinase (Syk) and phospholipase Cgamma (PLCgamma) of sensitized mast cells were activated by stimulation with DNP-HSA antigen, which was dampened by > or equal to 5 umol/L resveratrol. The phosphorylation of protein kinase C (PKC)u and PKCtheta was attenuated by administering resveratrol to DNP-HSA–exposed mast cells, whereas quiescent PKCzeta/lambda in sensitized cells was dose-dependently activated by resveratrol. Male BALB/c mice were sensitized for 24 h with DNP-IgE and orally administered with resveratrol 1 h before the DNP-HSA challenge.

The histamine concentration was enhanced in sensitized mice challenged to DNP-HSA, which was reversed by administration of 10 mg/kg resveratrol. Additionally, it encumbered the tissue activation of Syk, PLCgamma, and PKCu in antigen-exposed mice. Resveratrol decreased IgE-mediated PCA and alleviated allergic edema of mouse ear and dorsal skin. Mast cell degranulation and allergic inflammation, accompanying the induction of monocyte chemotactic protein-1 and macrophage inflammatory protein-2, were inhibited by supplementing resveratrol to antigen-challenged mice.

Resveratrol inhibited mast cell-derived, immediate-type allergic reactions, and these responses of resveratrol suggest possible therapeutic strategies in preventing allergic inflammatory diseases.

Source: J. Nutr. May 1, 2013 vol. 143 no. 5 632-639. Seon-Young Han, Ji-Young Bae, Sin-Hye Park, Yun-Ho Kim, Jung Han Yoon Park, and Young-Hee Kang.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Preserving Cognitive Function with Aging Preserving Cognitive Function with Aging
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing