ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

May 12 International ME/CFS, Lyme, and FM Awareness Day

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

The role of Epstein-Barr virus infection in the development of autoimmune thyroid diseases

Heroes Amidst the Daily Grind of Chronic Illness

Brain abnormalities in ME/CFS

Looking After Yourself Isn’t Selfish

Adapting Successfully to Long Term Illness – May Start with Dumping the Denial

Safely Burn Away Body Fat

In silico analysis of exercise intolerance in myalgic encephalomyelitis / chronic fatigue syndrome

 
Print Page
Email Article

Evidence of Brainstem Dysfunction in Fibromyalgia Patients

  [ 8 votes ]   [ 1 Comment ]
www.ProHealth.com • September 27, 2013


Alterations in excitatory and inhibitory brainstem interneuronal circuits in fibromyalgia: Evidence of brainstem dysfunction.

By M. Kofler and W. Halder

Abstract:

OBJECTIVE: Patients with fibromyalgia syndrome (FMS) perceive stimuli differently and show altered cortical sensory representation maps following peripheral stimulation. Altered sensory gating may play a causal role.

METHODS: Blink reflex, blink reflex excitability recovery, and prepulse inhibition of the blink reflex - representing brainstem excitability - were assessed in 10 female patients with FMS and 26 female healthy controls.

RESULTS:

  • Unconditioned blink reflex characteristics (R1 latency and amplitude, R2 and R2c latency and area-under-the-curve) did not differ significantly between patients and controls.

  • Blink reflex excitability recovery was enhanced in patients versus controls at all intervals tested.

  • Prepulses significantly suppressed R2 area and increased R2 latency in patients and controls.

  • However, R2 area suppression was significantly less in patients than in controls (patients: to 80.0±28.9%, controls: to 47.8±21.7%).

  • The general pattern of corresponding changes in R2c was similar.

CONCLUSIONS: Blink reflex is normal, whereas blink reflex excitability recovery is enhanced and blink reflex prepulse inhibition is reduced in patients with FMS, suggesting functional changes at the brainstem level in FMS.

SIGNIFICANCE: Reduced blink reflex prepulse inhibition concurs with altered sensory gating in patients with FMS.

Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Source: Clinical Neurophysiology, September 12, 2013. By M. Kofler and W. Halder. Department of Neurology, Hochzirl Hospital, Zirl, Austria.




Please Discuss This Article:   Post a Comment 

Interesting
Posted by: IanH
Sep 27, 2013
I studied reflex and other prepulse inhibition under the influence of cannabinoids. This same phenomenon occurs under the influence of many neurological drugs.
It also occurs in some forms of schizophrenia.

It implies to me that the immune system cyokines, probably Il-6 and TNF-alpha as well as chronically elevated IFN-gamma are behind this lack of excitation inhibition maybe via impaired neuron-mitochondrial function.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Cocoa's Polyphenol Riches – All the Health Benefits without the Sugar, Calories and Guilt Cocoa's Polyphenol Riches – All the Health Benefits without the Sugar, Calories and Guilt
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing