Activate Now
 
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ten Tips to Simplify, Lower the Cost, and Optimize CFS and fibromyalgia Treatment

Ampligen Takes Big Step Forward - Becomes First Drug Approved Anywhere For Chronic Fatigue Syndrome

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

Lipkin's Monster ME/CFS Study: Microbes, Immunity & Big Data

Keep Learning – Even From Bed!

Iron Man: A Young Person's POTS ME/CFS Recovery Story Pt. I

Buying Drugs from Canada - A Good Choice for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)?

VIDEO: Dear Healthy People: Fatigue

Researchers Identify Characteristic Chemical Signature for Chronic Fatigue Syndrome

SURVEY: Weight Management & Chronic Illness

 
Print Page
Email Article

Interstitial Cystitis may be considered a chronic inflammatory disease

  [ 1 vote ]   [ Discuss This Article ]
www.ProHealth.com • November 1, 2013


Editor's Comment: Interstitial cystitis is a common comorbidity among patients with ME/CFS and fibromyalgia. Dr. Jay Goldstein observed that 20% of his patients experienced pain upon urination, while other physicians have placed that percentage even higher (up to 90%). For those who suffer from this condition, constant bladder pain can be just as disabling as any other symptom. 

Increased Pro-Inflammatory Cytokines, C-Reactive Protein and Nerve Growth Factor Expressions in Serum of Patients with Interstitial Cystitis/Bladder Pain Syndrome

Yuan-Hong Jiang et al.

Abstract

Objective: The etiology and pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS) are unclear. Chronic inflammation is considered the main pathology of IC/BPS. This study measured the serum c-reactive protein (CRP), nerve growth factor (NGF) and pro-inflammatory cytokine/chemokine interleukin (IL)-1?, IL-6, tumor necrosis factor (TNF)-?, and IL-8 expression in patients with IC/BPS to elucidate the involvement of systemic inflammation in IC/BPS.

Methods: Serum samples were collected from 30 IC/BPS patients and 26 control subjects. The concentrations of serum nerve growth factor (NGF), IL-1?, IL-6, TNF-?, and IL-8 were quantified using a bead-based, human serum adipokine panel kit. Serum C-reactive protein

(CRP) was also assessed. Differences of serum CRP, NGF, IL-1?, IL-6, TNF-?, and IL-8 levels between the IC/BPS patients and controls were compared, and correlations between CRP and pro-inflammatory cytokines and chemokine were also evaluated.

Results: The results showed that CRP level (p = 0.031), NGF (p = 0.015) and pro-inflammatory cytokines/chemokine IL-1?, IL-6, TNF-?, and IL-8 levels were significantly higher in the patients with IC/BPS than among controls (all p<0.001). Significant associations were observed between IL-1? and IL-8 (p<0.001), IL-6 and CRP (p = 0.01), IL-6 and IL-8 (p = 0.02), and IL-6 and TNF-? (p = 0.03).

Conclusion: Increased pro-inflammatory cytokines/chemokine (IL-1?, IL-6, TNF-?, and IL-8) expression in the sera of IC/BPS patients implies not only mast cell activation, but also that other inflammatory mediators play important roles in the pathogenesis of IC/BPS. Thus, for some patients, IC/BPS is considered a chronic inflammatory disease.

SourcePLoS ONE 8(10): e76779 doi:10.1371/journal.pone.0076779.Jiang Y-H, Peng C-H, Liu H-T, Kuo H-C (2013) Increased Pro-Inflammatory Cytokines, C-Reactive Protein and Nerve Growth Factor Expressions in Serum of Patients with Interstitial Cystitis/Bladder Pain Syndrome. 





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® MitoQ® Hydroxocobalamin Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

"It's Not Easy Being Green" - But It Is Healthy
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map