Activate Now
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Misdiagnosis on a grand scale?

Myalgic encephalomyelitis, chronic fatigue syndrome: An infectious disease

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Cellular Havoc: Zeroing In On The Sleep Problems in Fibromyalgia?

Are All the "Feel-Good" Pathways Blocked in Fibromyalgia and Chronic Fatigue Syndrome?

Chronic Fatigue Syndrome, Fibromyalgia and Mitchondrial Disorders: A Comparison Plus the MitoQ Trial...

5 Things I've Learned About Chronic Illness Through Mindfulness

Increased Vulnerability to Pattern-Related Visual Stress in Myalgic Encephalomyelitis

Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR ...

VIDEO: New Developments in ME/CFS Research

Print Page
Email Article

Clonidine Treatment in Adolescent Chronic Fatigue Syndrome

  [ 3 votes ]   [ Discuss This Article ]
By Dag Sulheim, MD at al. • • February 19, 2014

Editor’s Comment: Sympathetic upregulation is common in patients with ME/CFS, and contributes to insomnia, migraines, nightmares, and feeling “tired and wired.” Clonidine inhibits sympathetic activity by reducing circulating epinephrine (adrenaline). Normally clonidine is used to treat high blood pressure, but off-label uses include sleep disorders, restless legs syndrome, anxiety disorders, and PTSD. While this study did not find clonidine effective for adolescents with ME/CFS, Dr. Jay Goldstein found that in adults it eliminated nightmares, reduced central pain, and, in  some patients, helped all symptoms. However, given the prevalence of orthostatic intolerance in adolescents with ME/CFS, it is not surprising that clonidine should have resulted in a reduction of physical activity (Stewart, 1999).Questions have also been raised concerning the ethics of testing drugs with potentially harmful side effects on ill children. (The age range in this study was 12-18 years.)

Disease Mechanisms and Clonidine Treatment in Adolescent Chronic Fatigue Syndrome: A Combined Cross-sectional and Randomized Clinical Trial

By Dag Sulheim, MD at al.


Importance: Chronic fatigue syndrome (CFS) is a disabling condition with unknown disease mechanisms and few treatment options.

Objective: To explore the pathophysiology of CFS and assess clonidine hydrochloride pharmacotherapy in adolescents with CFS by using a hypothesis that patients with CFS have enhanced sympathetic activity and that sympatho-inhibition by clonidine would improve symptoms and function.

Design, Setting, and Participants: Participants were enrolled from a single referral center recruiting nationwide in Norway. A referred sample of 176 adolescents with CFS was assessed for eligibility; 120 were included (34 males and 86 females; mean age, 15.4 years). A volunteer sample of 68 healthy adolescents serving as controls was included (22 males and 46 females; mean age, 15.1 years). The CFS patients and healthy controls were assessed cross-sectionally at baseline.

Thereafter, patients with CFS were randomized 1:1 to treatment with low-dose clonidine or placebo for 9 weeks and monitored for 30 weeks; double-blinding was provided. Data were collected from March 2010 until October 2012 as part of the Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial.

Interventions: Clonidine hydrochloride capsules (25 µg or 50 µg twice daily for body weight <35 kg or >35 kg, respectively) vs placebo capsules for 9 weeks.

Main Outcomes and Measures Number of steps per day.

Results: At baseline, patients with CFS had a lower number of steps per day (P?
There were no significant differences regarding blood microbiology evaluation. During intervention, the clonidine group had a lower number of steps per day (mean difference, ?637 steps; P?=?.07), lower plasma norepinephrine level (mean difference, ?42 pg/mL; P?=?.01), and lower serum C-reactive protein concentration (mean ratio, 0.69; P?=?.02) compared with the CFS placebo group.

Conclusions and Relevance: Adolescent CFS is associated with enhanced sympathetic nervous activity, low-grade systemic inflammation, attenuated hypothalamus-pituitary-adrenal axis function, cognitive impairment, and large activity reduction, but not with common microorganisms. Low-dose clonidine attenuates sympathetic outflow and systemic inflammation in CFS but has a concomitant negative effect on physical activity; thus, sympathetic and inflammatory enhancement may be compensatory mechanisms. Low-dose clonidine is not clinically useful in CFS.

Source: Dag Sulheim, MD; Even Fagermoen, MD; Anette Winger, RN; Anders Mikal Andersen, BSc; Kristin Godang, BSc; Fredrik Müller, MD, PhD; Peter C. Rowe, MD, PhD; J. Philip Saul, MD; Eva Skovlund, PhD; Merete Glenne Øie, PhD; Vegard Bruun Wyller, MD, PhD. JAMA Pediatr. Published online February 03, 2014. doi:10.1001/jamapediatrics.2013.4647

Post a Comment

Featured Products From the ProHealth Store
Hydroxocobalamin Extreme™ Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria

Natural Remedies

Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing