ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Interview: Jennifer Brea Talks About Obstacles, Adjustments, and Inspiration

Post-Exertional Debility is an Important Symptom during Myalgic Encephalomyelitis

Burmeister Wins Lawsuit: Court Rules Government Must Produce IOM Documents

Is the physical examination normal in CFS?

Traditional Chinese medicine for chronic fatigue syndrome: A systematic review of randomized clinica...

Symptoms of autonomic dysfunction in chronic fatigue syndrome

Irritable bowel syndrome and chronic fatigue six years after Giardia infection: a controlled prospec...

False Allegations of Child Abuse in Cases of Childhood Myalgic Encephalomyelitis (ME)

Your Rights When a Disability Claim is Terminated

From Our Readers: Comments & Suggestions – 9/10/14

 
Print Page
Email Article

Acetyl-L-Carnitine Effective in Treatment of Depression

  [ 7 votes ]   [ 1 Comment ]
www.ProHealth.com • March 14, 2014


Editor's comment: Depression is often a comorbidity with fibromyalgia. This study is a review of clinical trials evaluating the use of acetyl-l-carnitine in the treatment of depression. It includes a 2007 study that focused on the treatment of depressive symptoms in fibromyalgia patients.

Acetyl L-Carnitine (ALC) is a delivery form for L-carnitine, a vitamin-like nutrient that is responsible for transporting long chain fatty acid "fuel" into the cells' energy producing mitrochondria. ALC is able to travel through the blood-brain barrier and plays a role in formation of the brain chemical acetylcholine - a "neurotransmitter."

A review of current evidence for acetyl-l-carnitine in the treatment of depression.

By S.M. Want, et al.

Abstract:

Despite numerous antidepressants available, many patients with depression do not achieve adequate response rendering needs for novel antidepressants with different mechanism of actions. Acetyl-l-carnitine (ALC) is a potential antidepressant with novel mechanism of action because of its diverse functions related with neuroplasticity. Animal and cellular models suggest that ALC's neuroplasiticity effect, membrane modulation, and neurotransmitter regulation may play an important role in treatment of depression.

  • Four randomized clinical studies (RCT) demonstrated the superior efficacy of ALC over placebo (PBO) in patients with depression.

  • Two RCTs showed its superior efficacy over PBO in dysthymic disorder, and

  • 2 other RCTs showed that it is equally effective as fluoxetine and amisulpride in treatment of dysthymic disorder.

  • ALC was also effective in improving depressive symptoms in patients with fibromyalgia and minimal hepatic encephalopathy.

  • It was also found to be equally tolerable to PBO and better tolerable than fluoxetine and amisulpride.

In conclusion, ALC may be potentially effective and tolerable next treatment option with novel action mechanisms for patients with depression, in particular older population and patients with comorbid medical conditions who are vulnerable to adverse events from antidepressants. However, more clinical trial data with adequately-powered, well-designed and advanced methodology will be mandatory to conclude whether ALC as a monotherapy or augmentation agent may be efficacious and clinically beneficial for depression.

Copyright © 2014 Elsevier Ltd. All rights reserved.

Source: Journal of Psychiatric Research, February 15, 2014. Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU.




Please Discuss This Article:   Post a Comment 

Acetyl-L-Carnitine Effective in Treatment of Depression - Antidepressants
Posted by: herenow23
Mar 16, 2014
Aloha,

Naturally there are a lot of supplements that are available here which are very helpful. Supplements are especially helpful when we test levels of what we need and find the best way to stimulate our individual biological needs.

I am looking forward to the incorporation of this type of treatment being taught and practiced by all "practitioners". I hope that additional "accurate and unbiased" research for Acetyl-L-Carnitine Effective in Treatment of Depression is funded (if, it's "the best bang for the buck") and is effective. I hope all avenues are pursued and available to the public, properly researched and funded. I'm certain most of us can use all the help we can get.

Mahalos once again for the updates :)

23
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamin B-12

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness

Natural Remedies

VIDEO: Healthy Eating and Fibromyalgia VIDEO: Healthy Eating and Fibromyalgia
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing