Activate Now
 
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

There and Back Again – a CFS/Fibromyalgia Physician’s Recovery

Call to Action: Funding for ME/CFS Stricken From 2016 Federal Budget!

OMF's Severely Ill Patient Study Gets Large Donation

5 Health Strategies You Can Learn from Your Dog

Re-evaluating Your Habits

Increased Risk of Chronic Fatigue Syndrome Following Atopy: A Population-Based Study

Weeding Out Your Negative Thoughts!

Clinically Studied Joint Relief Product for FM & ME/CFS

Restoring Cellular Energy Metabolism

D-Ribose: Energize Your Heart, Save Your Life

 
Print Page
Email Article

Acetylcholinesterase inhibitors and Gulf War illnesses - Source: Proceedings of the National Academy of Sciences, Mar 10, 2008

  [ 407 votes ]   [ Discuss This Article ]
By Beatrice Golomb, MD, PhD • www.ProHealth.com • March 11, 2008


[Note: acetylcholinesterase inhibitors are used in "nerve agents," pesticides, and a pill (pyridostigmine bromide)that was administered to increase troop survival in case of nerve gas exposure They affect production of the neurotransmitter acetylcholine, and thus signal transmission at the neuromuscular junctions and in the brain.]

Increasing evidence suggests excess illness in Persian Gulf War veterans (GWV) can be explained in part by exposure of GWV to organophosphate and carbamate acetylcholinesterase inhibitors (AChEis), including pyridostigmine bromide (PB), pesticides, and nerve agents.

Evidence germane to the relation of AChEis to illness in GWV was assessed:

  • Many epidemiological studies reported a link between AChEi exposure and chronic symptoms in GWV.
  • The link is buttressed by a dose–response relation of PB pill number to chronic symptoms in GWV.
  • And by a relation between avidity of AChEi clearance and illness, based on genotypes, concentrations, and activity levels of enzymes that detoxify AChEis.

Triangulating evidence derives from studies linking occupational exposure to AChEis to chronic health symptoms that mirror those of ill GWV. Illness is again linked to lower activity of AChEi detoxifying enzymes and genotypes conferring less-avid AChEi detoxification.

AChEi exposure satisfies Hill's presumptive criteria for causality, suggesting this exposure may be causally linked to excess health problems in GWV.

[Note: To read a news story on the study, titled "Health problems in Persian Gulf War veterans higher due to chemical exposure," click here.]

Source: Proceedings of the National Academy of Sciences, March 10, 2008. [E-publication] 10.1073/pnas.0711986105, by Golomb BA, Department of Medicine, University of California, San Diego, California, USA. [E-mail: bgolomb@ucsd.edu]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness

Natural Remedies

Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Live Without Anxiety or Stress
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Coping When Colds or Flu Catch Up with You
Breaking Through the Mental Fog Breaking Through the Mental Fog

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing