ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Powerful Evidence That Chronic Fatigue Syndrome (CFS) And Fibromyalgia (FM) Are Real And Mainly Phys...

Study shows why exercise magnifies exhaustion for chronic fatigue syndrome patients

The Importance of Forgiveness When Living with Chronic Illness

5 Tips for Successfully Changing Your Diet

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

A Commercially Available Probiotic Reduces Chronic Fatigue Syndrome’s Inflammation—Should we offer t...

Evidence in chronic fatigue syndrome for severity-dependent upregulation of prefrontal myelination t...

The experience of sleep in chronic fatigue syndrome: A qualitative interview study with patients

Call to Action: Congressional Hearing on Ampligen

Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomye...

 
Print Page
Email Article

Acetylcholinesterase inhibitors and Gulf War illnesses - Source: Proceedings of the National Academy of Sciences, Mar 10, 2008

  [ 407 votes ]   [ Discuss This Article ]
By Beatrice Golomb, MD, PhD • www.ProHealth.com • March 11, 2008


[Note: acetylcholinesterase inhibitors are used in "nerve agents," pesticides, and a pill (pyridostigmine bromide)that was administered to increase troop survival in case of nerve gas exposure They affect production of the neurotransmitter acetylcholine, and thus signal transmission at the neuromuscular junctions and in the brain.]

Increasing evidence suggests excess illness in Persian Gulf War veterans (GWV) can be explained in part by exposure of GWV to organophosphate and carbamate acetylcholinesterase inhibitors (AChEis), including pyridostigmine bromide (PB), pesticides, and nerve agents.

Evidence germane to the relation of AChEis to illness in GWV was assessed:

  • Many epidemiological studies reported a link between AChEi exposure and chronic symptoms in GWV.
  • The link is buttressed by a dose–response relation of PB pill number to chronic symptoms in GWV.
  • And by a relation between avidity of AChEi clearance and illness, based on genotypes, concentrations, and activity levels of enzymes that detoxify AChEis.

Triangulating evidence derives from studies linking occupational exposure to AChEis to chronic health symptoms that mirror those of ill GWV. Illness is again linked to lower activity of AChEi detoxifying enzymes and genotypes conferring less-avid AChEi detoxification.

AChEi exposure satisfies Hill's presumptive criteria for causality, suggesting this exposure may be causally linked to excess health problems in GWV.

[Note: To read a news story on the study, titled "Health problems in Persian Gulf War veterans higher due to chemical exposure," click here.]

Source: Proceedings of the National Academy of Sciences, March 10, 2008. [E-publication] 10.1073/pnas.0711986105, by Golomb BA, Department of Medicine, University of California, San Diego, California, USA. [E-mail: bgolomb@ucsd.edu]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Eating Fat is Good… Maybe… Could Be… Sometimes Eating Fat is Good… Maybe… Could Be… Sometimes
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing