Activate Now
 
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fibromyalgia: Bad; Fibromyalgia with Migraine: Really Bad

Fibromyalgia and Sleep

4 Tips for Parenting with Chronic Illness

How Can You Be Positive When You Live With Chronic Pain?

Aching for Pain Relief?

Recovering from CFS and Fibromyalgia Series

Chocolate's Potential Health Benefits – and its Effect on Chronic Fatigue Syndrome Patients

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

4 Ways to Keep Spirits Up When in Chronic Pain

Finding Your Energy Envelope

 
Print Page
Email Article

CoQ10 supports reversal of statin-caused mitochondrial dysfunction, energy drain

  [ 19 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 11, 2012


Article:
Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance
- Source: Journal of Applied Physiology, May 31, 2012

By A Muraki, K Miyashita, et al.

[Note: Atorvastatin, aka Lipitor, is a lipophilic statin, meaning it dissolves in & is attracted to lipids (fats). Prevastatin, aka Pravachol, is a hydrophilic statin, meaning it dissolves in water, and so is believed to have less muscle penetration than lipophilic statins.]

Abstract:
Background: Statins are cholesterol-lowering drugs widely used in the prevention of cardiovascular diseases; however, they are associated with various types of myopathies.

Statins inhibit HMG-CoA reductase and thus decrease biosynthesis of low-density lipoprotein cholesterol and may also reduce ubiquinones, essential coenzymes of a mitochondrial electron transport chain, which contain isoprenoid residues, synthesized through an HMG-CoA reductase-dependent pathway.

Therefore, we hypothesized that statin treatment might influence physical performance:

• Through muscular mitochondrial dysfunction

• Due to ubiquinone deficiency.

Methods and Results:

The effect of two statins, atorvastatin and pravastatin, on ubiquinone content, mitochondrial function and physical performance was examined by using statin-treated mice.

Changes in energy metabolism in association with statin-treatment were studied by using cultured myocytes.

We found that atorvastatin-treated mice developed:

• Muscular mitochondrial dysfunction due to ubiquinone deficiency,

• And a decrease in exercise endurance,

• Without affecting muscle mass and strength.

Meanwhile, pravastatin at 10 times higher dose [than] atorvastatin had no such effects.

In cultured myocytes, atorvastatin-related decrease in mitochondrial activity led to:

• A decrease in oxygen utilization

• And an increase in lactate production.

Conversely, coenzyme Q10 treatment in atorvastatin-treated mice:

• Reversed atorvastatin-related mitochondrial dysfunction

• And a decrease in oxygen utilization,

• And thus improved exercise endurance.

Conclusion:

Atorvastatin decreased exercise endurance in mice through mitochondrial dysfunction due to ubiquinone deficiency.

Ubiquinone supplementation with coenzyme Q10 could reverse atorvastatin-related mitochondrial dysfunction and decrease in exercise tolerance.

Source: Journal of Applied Physiology, May 31, 2012. DOI:10.1152/japplphysiol.01362 by Muraki A, Miyashita K, Mitsuishi M, Tamaki M, Tanaka K, Itoh H. Keio University School of Medicine, Minato, Tokyo, Japan. [Email: miyakaza2sc.itc.keio.ac.jp]





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg Hydroxocobalamin Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

How Glutathione Can Save Your Life

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

FIBROMYALGIA
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
LYME DISEASE
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
FORUMS
Fibromyalgia
M.E. & CFS
Lyme Disease
General Health
WHOLESALE
AFFILIATES GUARANTEE
PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing