ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Twenty-Six Years of Hell: An ME/CFS/FM Recovery Story

The Opioid Painkiller Clampdown – Will it Lead to Better Drugs?

Could Chronic Fatigue Syndrome (ME/CFS) Be a Chronic Form of Sepsis?

An Alternative to Goals and Resolutions: Intentions and Extreme Permissiveness

Top 10 Gifts to People Living with Pain

In Their Own Words: Chronic Fatigue Syndrome and Fibromyalgia Patients Describe Their Symptoms – Par...

Unrest Flies High, Dr. Oz Talks ME/CFS and Ms Magazine Delivers

Urgency: Ron Davis and His (Non-NIH Funded) ME/CFS Collaborative Research Center

Podcast: Myra Christopher Discusses Undertreated Chronic Pain and the PAINS Project

Energy envelope maintenance among patients with myalgic encephalomyelitis and chronic fatigue syndro...

 
Print Page
Email Article

Defect in Immune Response Leads to Recurring Bladder Infections

  [ Not Yet Rated ]   [ Discuss This Article ]
www.ProHealth.com • February 20, 2013


Mast Cell Interleukin-10 Drives Localized Tolerance in Chronic Bladder Infection

– Source: Immunity, February 15, 2013

By Cheryl Y. Chan et al.

Highlights

  • MC-dependent immunosuppressive transcriptional program specific to the bladder
  • Local production of IL-10 results in suppressed humoral and cell-mediated responses
  • Multiple MC-deficient mouse models show tissue-specific immunosuppressive role of MC
  • Bladder is a site exhibiting an intrinsic degree of MC-maintained immune privilege

Summary: The lower urinary tract’s virtually inevitable exposure to external microbial pathogens warrants efficient tissue-specialized defenses to maintain sterility. The observation that the bladder can become chronically infected in combination with clinical observations that antibody responses after bladder infections are not detectable suggest defects in the formation of adaptive immunity and immunological memory. We have identified a broadly immunosuppressive transcriptional program specific to the bladder, but not the kidney, during infection of the urinary tract that is dependent on tissue-resident mast cells (MCs). This involves localized production of interleukin-10 and results in suppressed humoral and cell-mediated responses and bacterial persistence. Therefore, in addition to the previously described role of MCs orchestrating the early innate immunity during bladder infection, they subsequently play a tissue-specific immunosuppressive role. These findings may explain the prevalent recurrence of bladder infections and suggest the bladder as a site exhibiting an intrinsic degree of MC-maintained immune privilege.

Source: Immunity, 2013; DOI:10.1016/j.immuni.2012.10.019. Cheryl Y. Chan, Ashley L. St. John, Soman N. Abraham.





Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Ultra ATP+, Double Strength Hydroxocobalamin Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map