ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Unravelling the Mysteries of ME/CFS and Fibromyalgia: Meet the Man Behind the Book

How Myofascial Release Got Me Back On My Feet Again

16 Tips from 16 Years Sick

NIH announces centers for myalgic encephalomyelitis/chronic fatigue syndrome research

Cort Johnson Interviews ME/CFS Victor Martha Kilcoyne

Caregivers Draw Support By Mapping Their Relationships

Pediatric Chronic Pain: Prevalence, economic impact, and its relevance to the current opioid epidemi...

Ten Years with ME. This One May Take the Cake

Three NIH Funded ME/CFS Research Centers….and (What Else?) a Controversy

How Physical Therapists are Getting it About Chronic Fatigue Syndrome (ME/CFS)

 
Print Page
Email Article

Enhanced Glutathione Levels in Blood and Buccal Cells by Oral Glutathione Supplementation

  [ 8 votes ]   [ Discuss This Article ]
By John P Richie et al. • www.ProHealth.com • June 20, 2013


By John P Richie et al.

Abstract

Glutathione (GSH) is the major antioxidant in nearly all cells and plays numerous roles in protection against diseases and biological insults. Previous studies in laboratory animals indicate that orally administered GSH is bioavailable and effective at enhancing tissue GSH levels. The current objective was to determine the efficacy of GSH supplementation at enhancing body stores of GSH in healthy adults.

We conducted a 6-mo randomized, double-blind, placebo controlled trial to determine the impact of GSH administration at 250 mg/day and 1000 mg/day on GSH levels in different blood components and exfoliated buccal mucosal cells. Subjects were 54 healthy adults (41 females/13 males), 28–72 yr of age (mean=46.6 yr). Compliance was >90% by pill count.

After 6 mo in the high dose group, GSH levels were increased 30–35% in RBC, plasma, and lymphocytes and 260% in buccal cells (P<0.05). In most cases, the increases were dose and time dependent and levels returned to baseline after a 1-month washout. No significant changes were observed in levels of protein bound GSH.

A battery of immune function markers was also examined after 3 mo of GSH supplementation and Natural Killer (NK) cytotoxicity was enhanced > 2-fold in the high dose group (P<0.05). Altogether, these findings are consistent with previous pre-clinical studies and indicate that long-term oral administration GSH is an effective means of enhancing body stores of GSH.

Source: The FASEB Journal. 2013;27:862.32. John P Richie, Sailnendra Nichenametla, Ana Calcagnotto, Wanda Neidig, Todd Schell, and Joshua E Muscat





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Hydroxocobalamin Extreme™ B-12 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map