ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Exercise Intolerance in POTS, ME/CFS and Fibromyalgia Explained?

#ISpeakForPain Blitz

5 Ways That I Reduce Stress During Tough Times

Move More: How I Actually Started Exercising with a Chronic Condition

GUIDELINES FOR PAIN WARRIORS

8 Things to Consider for Depression

VIDEO: Living with Chronic Pain

ACTION ALERT: Improve US chronic pain care

Genes Highlight Inflammation and Mast Cells in Fibromyalgia

Moving Forward When a Treatment Proves Unsuccessful

 
Print Page
Email Article

Alpha-1 antitrypsin and chronic fatigue syndrome: a case study from pathophysiology to clinical practice

  [ 5 votes ]   [ 1 Comment ]
By J. Alegre et al. • www.ProHealth.com • April 8, 2014


Editor’s Comment: Alpha -1 Antitrypsin protects tissues from enzymes of inflammatory cells. The FDA has approved the use of three alpha 1-antitrypsin products derived from human plasma: Prolastin, Zemaira, and Aralast. Alpha -1 Antitrypsin treatment is extremely expensive.

By J. Alegre et al.

Abstract

Background: Several lines of evidence support the involvement of inflammatory and immunologic abnormalities in chronic fatigue syndrome (CFS). Since recent studies have shown that alpha-1 antitrypsin (AAT) possesses anti-inflammatory properties, the potential therapeutic effect of AAT treatment on CFS has been investigated.

Case presentation: A 49-year-old woman diagnosed with CFS was treated with intravenous infusions of a human plasma-derived AAT concentrate (60 mg/kg body weight weekly for 8 consecutive weeks). The patient's monocyte elastase, a regulator of inflammatory processes, was 1170 U/mg.

At completion of treatment, improvement in maximal workload was observed (54.0-71.7% of predicted). Additionally, amelioration in working memory (scores: 83-94) and perceptual organization (scores: 75-83) were detected on the Wechsler Adult Intelligence Scale-III test. Monocyte elastase decreased to a normal range (<150 U/mg).

Improvement in functional capacity allowed the patient to work in part-time employment.

Conclusion: These findings suggest a possible role for AAT in the treatment of CFS.

Source: Alegre J, Camprubí S, García-Quintana A. Pain Manag. 2013 Mar;3(2):119-22. doi: 10.2217/pmt.12.84.




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Hydroxocobalamin Extreme™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

A1AT study
Posted by: ashley96
Apr 24, 2014
A very interesting case report. Sadly this is a very expensive drug although a company in Italy were
apparently looking at a way of delivering the same via a nose spray a few years ago for A1At deficiency. They were bought up and nothing heard of it since. A few other studies are looking at
the wider impact of A1AT in other inflammatory disorders, as well as diabetes.Like everything else
cost will inevitably put a break on this promising area of research. Just a note, but it doesn't say if the patient had A1AT deficiency or not.
Greg
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map