ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Exercise Tests Suggest Autoimmunity Causes the Exertion Problems in Chronic Fatigue Syndrome, Fibrom...

Is Poor Sleep Pummeling the Immune System in ME/CFS and Fibromyalgia? A Vicious Circle Examined

Not Just an "Ill Person" - Ways to expand your identity when you're chronically ill

Is Chronic Fatigue Real?

Taking a Moment

VIDEO: Illness and Isolation

Inflammation correlates with symptoms in chronic fatigue syndrome

Recognizing the Needs of Pain Patients in Substance Use Policy

Staying Connected with Friends While Ill

Call Out the Imbalance in Current Policy Making for Pain Management and Prescription Opioid Use

 
Print Page
Email Article

“Flowers” in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue syndrome following infectious mononucleosis

  [ 11 votes ]   [ 1 Comment ]
By Carrie E Burdzinski • www.ProHealth.com • July 11, 2014


Editor's Comment: Dr. Leslie O. Simpson, a reseacher from New Zealand, has found abnormal red blood cells in patients with ME/CFS (1989, 1993,  1997, 2002). Dr. Simpson maintained that the presence of nondiscocyte red blood cells demonstrated that ME was an organic disease, and that the abnormal RBCs might be used for diagnosis. He also suggested that treatment could be aimed at correcting impaired capillary flow resulting from nondiscocyte cells. Abnormal RBCs are found in a number of disease processes.

By Carrie E Burdzinski

Abstract

Introduction: Chronic fatigue syndrome is a debilitating condition characterized by persistent fatigue, post-exertional malaise, myalgia, arthralgia, lymph node tenderness, impaired memory and concentration, autonomic irregularities, and other specific symptoms affecting multiple body systems.

Diverse hypotheses have been investigated to ascertain the disease etiology. Some of these include metabolic and mitochondrial deficiencies, exposure to environmental toxins, dysautonomia associated with orthostatic intolerance, autoimmune reactions, neuroendocrine aberrations, and chronic viral infections. However, a consistently observed biomarker for chronic fatigue has not been identified. A comprehensive, standardized strategy for accurate diagnosis and successful treatment remains elusive.

Case Report: A 28-year-old Caucasian female presented with chronic fatigue persisting for nine months following infectious mononucleosis.
Laboratory evaluation excluded classic causes of fatigue. Peripheral blood smear examination revealed numerous pairs of unusual nondiscocytic C-shaped erythrocytes, coupled in perpendicular crosses resembling four-petalled flowers. The presence of the erythrocyte pairs abated with the patient’s recovery from chronic fatigue syndrome over a 24-month period. This erythrocyte arrangement has not been reported elsewhere in medical literature.

Conclusion: A novel erythrocyte “flower” formation was identified in a patient with chronic fatigue syndrome. The presence of this arrangement paralleled the course of the illness and was no longer observed upon recovery. The physiological relevance of the structure remains a subject for future research. Several hypotheses are suggested, including enhanced membrane deformability resulting from elevated catecholamine levels, and immunemediated agglutination, possibly stemming from viral infection.

Source: Burdzinski, Carrie E “Flowers” in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue synd. rome following infectious mononucleosis. Int J Case Rep Images 2014;():*****.




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® B-12 Extreme™ MitoQ®


Article Comments Post a Comment

Fascinating!!!
Posted by: IanH
Jul 11, 2014
What a great confirmation of Simpson's earlier work.
Now we can see why the A-V shunts are activating and developing. Oversized erythrocytes and agglutinated erythrocytes cannot penetrate the capillary bed. They then bank up. Such "back-pressure" activates the A-V shunt or where there is no shunt one develops. The more the shunts are activated the less perfusion of muscle, skin, peripheral nerve and possibly even internal organs and glands.

As a consequence we have poor oxygenation, poor ROS and NOS clearance and reduced mitochondrial performance because of lowered mitochondrial membrane potential.

Things are starting to add-up.
Now we need to show why/how the immune system (infection) causes the change in erythrocyte behaviour and morphology.
Reply Reply
 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map