ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS

A Mestinon Miracle: Vagus Nerve Stimulating Drug Helps Long Time ME/CFS Patient Exercise

The Exercise Intolerance in POTS, ME/CFS and Fibromyalgia Explained?

#ISpeakForPain Blitz

5 Ways That I Reduce Stress During Tough Times

Move More: How I Actually Started Exercising with a Chronic Condition

GUIDELINES FOR PAIN WARRIORS

8 Things to Consider for Depression

Improve US chronic pain care

VIDEO: Living with Chronic Pain

 
Print Page
Email Article

Evidence that heightened pain perception in CFS is linked to oxidative stress

  [ 6 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 10, 2012


Article:
Modulation of the Axon-Reflex Response to Local Heat by Reactive Oxygen Species (ROS) in subjects with Chronic Fatigue Syndrome
- Source: Journal of Applied Physiology, Nov 8, 2012

By Marvin S Medow, PhD, et al.

[Note: Dr. Medow's research specialties include CFS, orthostatic dysfunction, nutrition, and cellular structure & function. Reactive oxygen species (ROS) are reactive molecules/free radicals – unstable molecules lacking an oxygen atom that are a byproduct of mitochondrial energy production. If not recycled by antioxidants, such as glutathione (which are able to donate a stabilizing oxgen atom to them without themselves becoming unstable), ROS steal oxygen atoms from other molecules in the cell, which in turn are unstabilized, and so on, creating a cell damaging chain reaction. This state is called “oxidative stress.”]

Abstract:
Local cutaneous heating causes vasodilation as an initial first peak, a nadir, and increase to plateau. Reactive oxygen species (ROS) modulate the heat plateau in healthy controls. The initial peak, due to C-fibre nociceptor-mediated axon reflexes, is blunted with local anesthetics, and may serve as a surrogate for the cutaneous response to peripheral heat.

Chronic Fatigue Syndrome (CFS) subjects report increased perception of pain.

To determine the role of ROS in this neurally-mediated response, we evaluated changes in cutaneous blood flow from local heat in 9 CFS subjects (16-22 years) compared to 8 healthy controls (18-26 years).

We heated skin to 42°C and measured local blood flow as a percentage of maximum cutaneous vascular conductance (%CVC(max)).

While CFS subjects had significantly lower baseline flow (8.75+/-0.56 vs. 12.27+/-1.07 (%CVC(max) , CFS vs. control)), there were no differences between groups to local heat.

We then re-measured this with apocynin to inhibit NADPH oxidase, allopurinol to inhibit xanthine oxidase, tempol to inhibit superoxide, and ebselen to reduce H(2)O(2).

Apocynin significantly increased baseline blood flow (before heat, 14.91+/-2.21 vs. 8.75+/-1.66) and the first heat peak (69.33+/-3.36 vs. 59.75+/-2.75).

Allopurinol and ebselen only enhanced the first heat peaks (71.55+/-2.48 vs. 61.72+/-2.01 and 76.55+/-5.21 vs. 58.56+/-3.66, respectively).

Tempol had no effect on local heating.

None of these agents changed the response to local heat in control subjects.

Thus the response to heat may be altered by local levels of ROS, particularly H(2)O(2) [hydrogen peroxide] in CFS subjects, and may be related to their hyperesthesia/ hyperalgesia [abnormally increased sensitivity/pain perception].

Source: Journal of Applied Physiology, Nov 8, 2012. PMID:23139367, by Medow MS, Aggarwal A, Baugham IL, Messer ZR, Stewart JM. New York Medical College, Valhalla, New York, USA. [Email: marvin_medow@nymc.edu]





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® MitoQ® Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map