ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

A Thief Of Dreams

“Death Rider:” A (Hopeful) Mold Illness Story

May 12 ME/CFS International Awareness Day 2017 - Events and Activities

When Your Kids Are Chronically Ill

Letting Go of Negative Thoughts and Finding My Center

Live Like You’re Dying

Preserving our Cognitive Skills with Coenzyme Q10 Plus Selenium

Maternal Chronic Pain Study is Actively Seeking Participants

The spread of EBV to ectopic lymphoid aggregates may be the final common pathway in the pathogenesis...

When You Have to Cancel Your Plans

 
Print Page
Email Article

Inflammation in the gut may lead to the proliferation of unhealthy gut flora

  [ 3 votes ]   [ 1 Comment ]
www.ProHealth.com • February 23, 2013


Editor's Comment: This piece of research directly supports Martin Pall's hypothesis that the production of excess nitric oxide is the basic mechanism behind ME/CFS. According to Pall, the symptoms of ME/CFS and other multi-system illnesses can be explained by a vicious cycle of inflammation created by nitric oxide and its breakdown products. This study also provides an explanation for the gut flora abnormalities and subsequent gastrointestinal problems commonly experienced by people with ME/CFS, IBS, autism, and fibromyalgia.

Host-derived nitrate boosts growth of E. coli in the inflamed gut.

~Source: Science. February 8, 2013.

By SE Winter et al.

Abstract

Changes in the microbial community structure are observed in individuals with intestinal inflammatory disorders. These changes are often characterized by a depletion of obligate anaerobic bacteria, whereas the relative abundance of facultative anaerobic Enterobacteriaceae increases. The mechanisms by which the host response shapes the microbial community structure, however, remain unknown. We show that nitrate generated as a by-product of the inflammatory response conferred a growth advantage to the commensal bacterium Escherichia coli in the large intestine of mice. Mice deficient in inducible nitric oxide synthase did not support the growth of E. coli by nitrate respiration, suggesting that the nitrate generated during inflammation was host-derived. Thus, the inflammatory host response selectively enhances the growth of commensal Enterobacteriaceae by generating electron acceptors for anaerobic respiration.

Source: Science. 2013 Feb 8;339(6120):708-11. doi: 10.1126/science.1232467. Winter SE, Winter MG, Xavier MN, Thiennimitr P, Poon V, Keestra AM, Laughlin RC, Gomez G, Wu J, Lawhon SD, Popova IE, Parikh SJ, Adams LG, Tsolis RM,Stewart VJ, Bäumler AJ. Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA, USA.

Additional information about this study can be found at Science Daily.




Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ MitoQ® Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Pall, possibly
Posted by: IanH
Feb 23, 2013
The key statement from the authors is "We show that nitrate generated as a by-product of the inflammatory response"

The key is "inflammatory response" which is now well established in ME/CFS.
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Breaking Through the Mental Fog Breaking Through the Mental Fog
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map