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The effects of exercise on dynamic sleep morphology in healthy controls and patients with chronic fatigue syndrome

  [ 7 votes ]   [ 2 Comments ]
By Akifumi Kishi et al. • • January 16, 2014

Editor's Comment: Unrefreshing sleep is one of the hallmark symptoms of ME/CFS. Patients report feeling just as tired, if not more so, after waking. Few studies have attempted to pinpoint the source of unrefreshing sleep. In this study, the researchers found that exercise, while improving deep sleep in both healthy controls and patients, led to increased wakings from REM sleep (dreaming) in patients with CFS. The authors found that "the sustained feeling of increased fatigue in CFS could be due to disruption of REM sleep.

By Akifumi Kishi et al.


Effects of exercise on dynamic aspects of sleep have not been studied. We hypothesized exercise altered dynamic sleep morphology differently for healthy controls relative to chronic fatigue syndrome (CFS) patients.

Sixteen controls (38 ± 9 years) and 17 CFS patients (41 ± 8 years) underwent polysomnography on baseline nights and nights after maximal exercise testing. We calculated transition probabilities and rates (as a measure of relative and temporal transition frequency, respectively) between sleep stages and cumulative duration distributions (as a measure of continuity) of each sleep stage and sleep as a whole.

After exercise, controls showed a significantly greater probability of transition from N1 to N2 and a lower rate of transition from N1 to wake than at baseline; CFS showed a significantly greater probability of transition from N2 to N3 and a lower rate of transition from N2 to N1.

These findings suggest improved quality of sleep after exercise. After exercise, controls had improved sleep continuity, whereas CFS had less continuous N1 and more continuous rapid eye movement (REM) sleep.

However, CFS had a significantly greater probability and rate of transition from REM to wake than controls. Probability of transition from REM to wake correlated significantly with increases in subjective fatigue, pain, and sleepiness overnight in CFS – suggesting these transitions may relate to patient complaints of unrefreshing sleep.

Thus, exercise promoted transitions to deeper sleep stages and inhibited transitions to lighter sleep stages for controls and CFS, but CFS also reported increased fatigue and continued to have REM sleep disruption. This dissociation suggests possible mechanistic pathways for the underlying pathology of CFS.

Source: Akifumi Kishi, Fumiharu Togo, Dane B. Cook, Marc Klapholz, Yoshiharu Yamamoto, David M. Rapoport, Benjamin H. Natelson. The effects of exercise on dynamic sleep morphology in healthy controls and patients with chronic fatigue syndrome. Physiological Reports, November 13, Volume 1, Issue 6, November 2013. DOI: 10.1002/phy2.152

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Article Comments Post a Comment

Excercise and Sleep
Posted by: gemini52
Jan 16, 2014
This ends up being an undecided article. More comfusing than informative. Exercise can help you sleep better. Just make sure you exercise at least 4-6 hours prior to going to bed, if you can.
Reply Reply

Posted by: IanH
Jan 16, 2014
Depression is the opposite of this. The more a depression sufferer exercises the more continuous their sleep.

This result is to be expected and we find that those with ME who exercise more strongly have more sleep wakenings. However very gradual development of exercise improves all aspects of sleep. Unfortunately there is a tendency to either overdo it or not do it at all.

We need physiotherapists to learn better understanding of ME in order to counsel people with ME for exercise.
Reply Reply
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