ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Study Suggests “Bad Energy” is Core Problem in Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)

Travel Tips for the Chronically Ill

One of Our Strongest Allies Needs Our Help! Please read!

The Genetic Mutation That May Compromise Your Health - And What to Do About It

Getting Clear on Ketogenic Diets (for Fibromyalgia and ME/CFS): A Review

Could we finally have a definitive biomarker for ME/CFS?

Endogenous Pain Facilitation Rather Than Inhibition Differs Between People with Chronic Fatigue Synd...

ME/CFS Research Community Surprises: Submits Ten Research Center Applications to NIH

Making Music – and a Difference – for ME/CFS

The Scientist, the Seahorse and the Nanoneedle – Catching Up with Ron Davis on ME/CFS

 
Print Page
Email Article

“Flowers” in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue syndrome following infectious mononucleosis

  [ 11 votes ]   [ 1 Comment ]
By Carrie E Burdzinski • www.ProHealth.com • July 11, 2014


Editor's Comment: Dr. Leslie O. Simpson, a reseacher from New Zealand, has found abnormal red blood cells in patients with ME/CFS (1989, 1993,  1997, 2002). Dr. Simpson maintained that the presence of nondiscocyte red blood cells demonstrated that ME was an organic disease, and that the abnormal RBCs might be used for diagnosis. He also suggested that treatment could be aimed at correcting impaired capillary flow resulting from nondiscocyte cells. Abnormal RBCs are found in a number of disease processes.

By Carrie E Burdzinski

Abstract

Introduction: Chronic fatigue syndrome is a debilitating condition characterized by persistent fatigue, post-exertional malaise, myalgia, arthralgia, lymph node tenderness, impaired memory and concentration, autonomic irregularities, and other specific symptoms affecting multiple body systems.

Diverse hypotheses have been investigated to ascertain the disease etiology. Some of these include metabolic and mitochondrial deficiencies, exposure to environmental toxins, dysautonomia associated with orthostatic intolerance, autoimmune reactions, neuroendocrine aberrations, and chronic viral infections. However, a consistently observed biomarker for chronic fatigue has not been identified. A comprehensive, standardized strategy for accurate diagnosis and successful treatment remains elusive.

Case Report: A 28-year-old Caucasian female presented with chronic fatigue persisting for nine months following infectious mononucleosis.
Laboratory evaluation excluded classic causes of fatigue. Peripheral blood smear examination revealed numerous pairs of unusual nondiscocytic C-shaped erythrocytes, coupled in perpendicular crosses resembling four-petalled flowers. The presence of the erythrocyte pairs abated with the patient’s recovery from chronic fatigue syndrome over a 24-month period. This erythrocyte arrangement has not been reported elsewhere in medical literature.

Conclusion: A novel erythrocyte “flower” formation was identified in a patient with chronic fatigue syndrome. The presence of this arrangement paralleled the course of the illness and was no longer observed upon recovery. The physiological relevance of the structure remains a subject for future research. Several hypotheses are suggested, including enhanced membrane deformability resulting from elevated catecholamine levels, and immunemediated agglutination, possibly stemming from viral infection.

Source: Burdzinski, Carrie E “Flowers” in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue synd. rome following infectious mononucleosis. Int J Case Rep Images 2014;():*****.




Post a Comment

Featured Products From the ProHealth Store
Hydroxocobalamin Extreme™ Energy NADH™ 12.5mg B-12 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Fascinating!!!
Posted by: IanH
Jul 11, 2014
What a great confirmation of Simpson's earlier work.
Now we can see why the A-V shunts are activating and developing. Oversized erythrocytes and agglutinated erythrocytes cannot penetrate the capillary bed. They then bank up. Such "back-pressure" activates the A-V shunt or where there is no shunt one develops. The more the shunts are activated the less perfusion of muscle, skin, peripheral nerve and possibly even internal organs and glands.

As a consequence we have poor oxygenation, poor ROS and NOS clearance and reduced mitochondrial performance because of lowered mitochondrial membrane potential.

Things are starting to add-up.
Now we need to show why/how the immune system (infection) causes the change in erythrocyte behaviour and morphology.
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map