ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Chronic Christmas: Surviving the Holidays with a Chronic Illness

Beginning Again: Living with the Ups and Downs of Life with Chronic Illness

Happiness, Gratitude and Appreciation

Productivity Values That Get in the Way of Our Health

The Other Side Of ME/CFS/POTS – A Partner’s Perspective

VIDEO: Why Things Hurt

The “Starvation” Disease? Metabolomics Meets Chronic Fatigue Syndrome Down Under

NIH Stumbles: Asks ME/CFS Denier to Speak on Chronic Fatigue Syndrome

The IACFS/ME 2016 Conference Overviews #1: Energy and Exercise To the Fore

 
Print Page
Email Article

Explaining ME/CFS as immune system’s ‘Pavlov’ response to persistent EBV

  [ 23 votes ]   [ 2 Comments ]
www.ProHealth.com • August 10, 2012


Article:
Can persistent Epstein-Barr virus infection induce chronic fatigue syndrome as a Pavlov reflex of the immune response?
– Source: Journal of Biological Dynamics, Jan 2012 (final version of record online Jul 16, 2012)

By Elena Agliari, et al.

[Note: To view the free full text of this article proposing a unifying theory of the etiology of chronic fatigue syndrome / myalgic encephalomyelitis (ME/CFS), CLICK HERE. The article includes some intriguing, plain-language background sections and some very complex, formula-heavy statistical sections. The ‘Pavlov’ response refers to how physiological responses can become conditioned to occur without the initial stimulus - e.g., Pavlov's dogs salivating at the sound of a bell that once accompanied feeding time.]

Abstract:
Chronic fatigue syndrome is a protracted illness condition (lasting even years) appearing with strong flu symptoms and systemic defiances by the immune system.

• Here, by means of statistical mechanics techniques, we study the most widely accepted picture for its genesis, namely a persistent acute mononucleosis infection,

• And we show how such infection may drive the immune system towards an out-of-equilibrium metastable state displaying chronic activation of both humoral and cellular responses (a state of full inflammation without a direct 'causes-effect' reason).

By exploiting a bridge with a neural scenario, we mirror killer lymphocytes T(K) and B cells to neurons and helper lymphocytes

[Formula: see text] and [Formula: see text] to synapses, hence showing that the immune system may experience the Pavlov conditional reflex phenomenon:

• If the exposition to a stimulus (Epstein-Barr virus antigens) lasts for too long,

• Strong internal correlations among B cells, killer lymphocyte T(K) and T(H) may develop

• Ultimately resulting in a persistent activation even though the stimulus itself is removed.

These outcomes are corroborated by several experimental findings.

Source: Journal of Biological Dynamics, Mar 2012;6(2):740-62 – full text of record online Jul 16, 2012. PMID:22873615, by Agliari E, Barra A, Vidal KG, Guerra F. Dipartimento di Fisica, Università degli Studi di Parma, Parma, Italy. [Email: elena.agliari@fis.unipr.it]





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Hydroxocobalamin Extreme™ MitoQ®


Article Comments Post a Comment

This was disproved in the 1980's
Posted by: spacee
Aug 10, 2012
Dr. Steven Straus was most unhappy for it to be disproved and began cursing when he read
the report.

Yet, I do have hope that we have better testing available in the 21st century. And that some
help for those who need it comes from the testing.
Reply Reply

Good News/Bad News
Posted by: Mikie
Aug 31, 2012
The good news is that if anyone ever finds the mechanism of our immune systems' overreaction to one infection, it may explain how our immune systems overreact to other infections. The bad news is that not everyone with our illnesses had them triggered by the EBV. My own illness was triggered full blown my a mycoplasma infaction. Most of us have had an EBV infection or been exposed to it. It never goes away so it is possible that EBV sets us up for our illnesses; however, I believe there is a genetic factor which might help explain why we overreact to pathogens.

Love, Mikie
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map